u/Dumbledore27

I recently turned 30 and for the last couple of years I have noticed that my diabetes is… changing?

I’ve had t1 for 20 years now, and for the vast majority of that time my issues were centered around high blood sugars. For whatever reason, that’s changed recently. I seem to go low all the time. Sometimes I really struggle to get my blood sugar up, even after guzzling juice/eating. I’ve adjusted my basal rates accordingly, and while it has helped, I’m still dealing with frequent lows.

I know that this disease can change with age. I’m thinking this may be one of the ways it’s changing for me?

An annoying part of always going low is the weight/fat I’ve gained as a result. Since I’m always drinking juice and consuming a lot of refined sugars, I have gained a considerable amount of fat/weight. It’s frustrating because it seems like there’s no way around this. Obviously I can’t just ignore a low and hope that it goes away eventually.

The solution may to just keep reducing my basal rates and correction factor. I’m just curious if anyone else here has underdone similar changes with age?

I’ve been on compounded semaglutide for over a year now (14 months) and have worked my way up to 2.5 mg at 70 units a dose.

I have lost nothing but muscle mass since being on this medication. I have gained a substantial amount of body fat, and it’s noticeable. My body fat has risen 5% since late October.

I wasn’t that overweight when I started, and I HAVE lost weight (15 lbs), but I suspect it’s mostly been muscle loss.

My hunger levels were noticeably different when I started - the food noise is still less intense now, but my hunger levels have pretty much returned to normal.

The medication has made my blood sugar go LOW very, very frequently. I’m a type 1 diabetic but was still approved for weight loss. My blood sugar goes through several low periods on a daily basis, and I correct them by drinking juice/soda/etc. I feel as though I am constantly drinking my calories - and the excess sugar is probably what caused the fat gain.

I feel more self conscious about my body and weight than ever before. The lethargy and awful gi side affects have made me realize that this medication just isn’t worth it for me. It’s just not working for body. It’s upsetting to come to this realization, but it is what it is.

So, if you’re out there and wondering why this medication does nothing for you… just know you’re not alone! This medication doesn’t work for many people.

I'm a T1 Diabetic and have been for 21 years now. I grew up going to a major Diabetes clinic in Boston, where researchers are continuously making groundbreaking discoveries in all kinds of new and exciting diabetes treatments. Being in such close proximity to that work, even as a child, was inspiring. It's always been a goal of mine to work in proximity with research like this, or in diabetes care generally.

The thing is, I was never very good at science or math (at least in high school, which was now over a decade ago). I was never fit for a STEM undergrad degree. I was, however, good at writing and design (right brain FTW).

At my last job, I worked as a comms and creative lead for a public health / disaster response research team/department at a university. This was an AWESOME job. It perfectly blended my interests in health and my talents in writing and design. I wrote and designed research briefs reports, helped with research infographics and visualizations, helped publish and disseminate data reports during public health emergencies and natural disasters... It was such purposeful, meaningful work. I cultivated such a strong relationship with the faculty and PIs I worked with there, and constantly felt energized and inspired by the work they did.

While the job was great, the stability/security of my role was always in flux because my pay came from internal university funds and external research grants. These weren't always guaranteed, obviously, and the shifting priorities of the university's office of the Vice Provost for research made it so the future of my job was always somewhat unclear.

When Trump got reelected it kind of all went to shit and the research was gutted. A lot of things had to be moved around. Public health and medical research is still a bit of shit show, especially in academia, and probably will be for the next 2+ years.

I could sense things were getting tense and the future of the research was becoming more and more uncertain towards the end of 2023/early 2024. When I sensed things were shaking up behind the scenes, I decided to apply elsewhere and got a job at another university across the country. I knew the job wouldn't be one I like, but I wanted something that felt consistent and stabile. Also, I desperately wanted to get out of the state I was living in (bad, long winters made me very depressed).

I've been at this "new" job for over 2 years now, and I'll admit it's very secure and "cushy." I feel underutilized and under-appreciated, though, and the work I do is so far removed from what I'm passionate about that I feel drained and burnt out. Like fatigue or malaise. I don't feel challenged. I'm not learning anything. I'm not doing work that I actually care about. I'm not doing work that is actually helping people.

The job I had previously is rare, and similar ones are nearly impossible to come by nowadays.

I know I need a change, I just don't know how to do it. I'd love to pivot back to what I was doing - or something similar to it.

I still have very strong relationships with the PIs I worked with at my previous job. I consider the main PI a good friend and lifelong mentor. I know I could reach out to him and ask for leads/help, but I do feel a bit weird doing so after I left their team (he was not happy with my decision to leave - especially for a job he knew didn't align with my passions).

I regret not trying to get a Masters degree when I was a bit younger because I feel like it would've given me more options at this point. It's hard to find comms/design jobs in medical research.

It doesn't even have to be writing or design-based. I'd also love a career where I interface with people regularly - where the work hinges on real, human relationships. I can't live my life behind a screen or at a desk. It's driving me insane.

My last job was essentially a PhD program. I worked under faculty researchers and with other PhD researchers and fellows (I wasn't doing any of the nitty gritty science-y analysis, though). I regret not exploring a post-grad degree program/ or more research-focused path like that. I am naturally curious and think I'd really thrive in a program like that, though I'd worry about having enough money.

I would love to work somewhere like the International Diabetes Federation, a diabetes-focused research center at a hospital or university, or some sort of diabetic NGO, but I don't have the STEM background I need to break into those spaces.

Does anyone have any insight or thoughts? I'm open to all feedback and recommendations!