r/Renue | reddlx

Fisetin, How to match the Mayo senolytic protocol?

I’ve been looking into senolytic cycling and I’m stuck on the best way to dose this stuff.

The original mayo protocol calls for about 20 mg/kg of regular fisetin for two days in a row each month. For someone my size that works out to roughly 1500 mg of standard fisetin per day.

Renue’s liposomal fisetin claims higher bioavailability, which would mean just 2 capsules (300 mg total) should theoretically hit or even beat that Mayo dose.

Option 1: Buy regular fisetin and just follow the exact studied protocol

Option 2: Go with the liposomal version and use the lower dose

My worry is either under-dosing (and wasting the cycle) or accidentally going way too high if the bioavailability is as good as advertised. I definitely want the senolytic hit, but I don’t want to overdo it either.

Appreciate any real-world experiences!

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u/TheJordanator10 — 2 days ago

▲ 17 r/Renue+1 crossposts

STUDY: New Human Data Challenges the “Universal NAD+ Decline With Age” Model

A new review of recent human NAD+ research argues that the classic narrative, “NAD+ declines with age”, is probably too simplistic.

Key Points

• Whole-blood NAD+ does not consistently decline with age in newer studies
• Tissue NAD+ (muscle, skin, brain) often does decline with aging
• Physically active older adults can maintain youthful muscle NAD+ levels
• NAD+ response to supplementation varies substantially between individuals
• Blood NAD+ may reflect intervention response better than biological aging itself

This is an important shift in the field. The newer data doesn’t invalidate NAD+ biology but gives it new nuance. The emerging picture is that NAD+ appears to be:

• Tissue-specific
• Highly dynamic
• Influenced by health status, activity level, and disease burden
• More individualized than previously thought

This is a reminder that biomarkers measured in blood don’t always represent what’s happening inside active tissues.

Full Article: https://renuebyscience.com/blogs/scientific-evidence-library/nad-aging-blood-biomarker-human-study

u/Environmental_Oil144 — 4 days ago

▲ 5 r/Renue

STUDY: NR + Exercise Improves Fitness in Friedreich’s Ataxia

A 2026 trial examined whether combining NR with structured exercise could improve fitness in people with Friedreich’s ataxia, a neurodegenerative condition associated with mitochondrial dysfunction and impaired energy production.

Key Points

• NR + exercise increased VO2 by ~12.7%
• Exercise alone improved VO2 by ~9.5%
• NR alone improved VO2 by ~5%
• Control group declined by ~2.4%

The strongest effects came from combining NAD+ support with exercise, which fits the broader idea that raising NAD+ may work best when paired with mitochondrial activity and adaptation.

Full Article: https://renuebyscience.com/blogs/scientific-evidence-library/nr-exercise-improves-fitness-in-friedreichs-ataxia

u/Renue_Support — 9 days ago