u/Advanced-Addendum230

IM faculty here, I'm sharing some tips for you, your students, or residents. This week let’s talk about Syncope (Topic 7 of 8).

IM faculty here, I'm sharing some tips for you, your students, or residents. This week let’s talk about Syncope (Topic 7 of 8).

Passed out + woke up quickly = think true syncope → transient complete loss of consciousness from global cerebral hypoperfusion with rapid, full recovery.

The 4 buckets you need to know:

Reflex (vasovagal) – most common
Younger patients. Triggered by pain, fear, heat, coughing, urination, etc.
Prodrome = nausea + diaphoresis → often fatigue afterward.

Cardiac – highest mortality
Arrhythmias most common, but also structural disease, PE, etc.
Red flags: no prodrome, sudden drop, exertional or supine syncope, chest pain, palpitations.

Orthostatic
Older adults. Happens after standing. Think dehydration, meds, alcohol, autonomic dysfunction (e.g., Parkinson disease, Diabetes Mellitus).

Psychogenic (pseudosyncope)
Often younger patients with anxiety/depression.
Think seizure instead if aura, abnormal posturing, tongue biting, head turning, prolonged confusion.

Board pearls:
Every patient gets an ECG.
Exertional or supine syncope = cardiac until proven otherwise.
No brain CT/MRI unless focal neurologic deficits.
Carotid ultrasound has no role.
Tilt-table testing = only if suspected recurrent vasovagal/orthostatic after unrevealing initial workup.
PE can present as syncope, don’t miss it.

Admit / urgent cardiac eval if:
Exertional or supine syncope
Chest pain or palpitations
Known heart disease
Family history of sudden death
Hypotension/bradycardia
Abnormal ECG

One-liner:
Nausea + sweating before = vasovagal. Sudden collapse with no warning = cardiac until proven otherwise.

If you want to read more similar clinical tips for your practice and exam, Subscribe to my Substack here. I post regularly over there but will continue to post here periodically!

American College of Cardiology / American Heart Association 2017 syncope guidelines.

u/Advanced-Addendum230 — 8 days ago

Dropped everything I know about C. diff into one post. This is the version I wish I had before my boards. Save it.

>RISK FACTORS

Antibiotics — any antibiotic, not just broad-spectrum. Biggest trigger.

Older age, IBD, solid organ transplant, GI surgery

PPIs — possible association, boards love testing this

Incubation up to 3 months after antibiotic use, always ask carefully

>>Alcohol hand gel does NOT kill spores. Soap and water ONLY. This is tested.

>PRESENTATION

Watery diarrhea (rarely bloody), fever, crampy pain, leukocytosis, ↑Cr

Fulminant: toxic megacolon, ileus, hypotension, shock → needs surgery consult

>DIAGNOSIS

Only test unformed stool, no laxatives, ≥3 new stools/day. Testing formed stool = classic trap.

NAAT (PCR)

Best test. Sensitive + specific. Sufficient alone when stool criteria met.

EIA toxin A+B

Specific but not sensitive. Used in multistep approach.

GDH EIA

Sensitive, not specific. Screening step only — always pair with toxin.

Multistep (GDH + toxin ± NAAT)

Use when stool submission criteria aren't strictly met.

>Do NOT retest asymptomatic patients after treatment. PCR stays + for weeks = meaningless.

>INITIAL TREATMENT

Stop the offending antibiotic if possible. Fidaxomicin > vancomycin (lower recurrence). Metronidazole is dead as first-line.

Nonsevere

Fidaxomicin 200 mg BID × 10d (preferred)

Vancomycin 125 mg QID × 10d (alternative)

Metronidazole 500 mg TID × 10–14d (only if above unavailable)

Severe : WBC ≥15k or Cr ≥1.5

Fidaxomicin 200 mg BID × 10d (preferred)

Vancomycin 125 mg QID × 10d (alternative)

Fulminant: shock / hypotension / toxic megacolon / ileus

Vancomycin 500 mg QID PO or NGT

+ Metronidazole 500 mg q8h IV

If ileus → add Vancomycin 500 mg PR q6h

→ Surgical evaluation. No exceptions.

 

RECURRENT C. DIFF

25% of patients relapse. Each episode ↑ risk of the next.

1st recurrence

Fidaxomicin 200 mg BID × 10d (preferred)

Vancomycin taper: QID × 10–14d → BID × 7d → QD × 7d → q2–3d × 2–8 wk

2nd+ recurrence

Fidaxomicin BID × 10d or extended pulse

Vancomycin taper (as above)

Vancomycin × 10d → Rifaximin 400 mg TID × 20d

Fecal microbiota products, FDA approved (oral capsule or rectal suspension)

ONE-LINERS

-Soap and water only, alcohol gels don't kill spores

-Fidaxomicin preferred for ALL severities over vancomycin

-Metronidazole = last resort only (not even second-line anymore)

-Fulminant = vanco PO/NGT + IV metro ± vanco PR + surgery consult

-No loperamide. No antimotility. Ever.

-Don't retest stool in asymptomatic patients after treatment

-Fecal microbiota products = FDA approved for recurrent CDI prevention

If you want more details, refer to my Substack here. I post regularly over there but will continue to post here periodically!

Johnson, S., Lavergne, V., Skinner, A. M., Gonzales-Luna, A. J., Garey, K. W., Kelly, C. P., & Wilcox, M. H. (2021). Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America73(5), e1029–e1044. https://doi.org/10.1093/cid/ciab549

 

 

u/Advanced-Addendum230 — 28 days ago