u/Agreeable-Read-3367

5 years ago I was on trt. For 6month everything was fine. I had a full head of hair, almost 0hairs on my hands when showering. Month 6 I took anastrazole and crashed hard. My testicles downsized within days after the crash I had severe brain fog for 6month after pct. I could not get an erections and my libido is still zero. Diffusive hairloss started and never stopped, I don’t know why I don’t have any micronutritient deficits. Now I have the hairloss and no libido with watery semen. My testicles are back to normal.My blood labs all look normal but I have the ugt2b17 deletion. Any idea how to stop the hairloss? I’m not willing to try roids because they give me 0 effect on libido. I tried 1500iu hcg e3d and I was back to normal but it worked only 4months then no effect even after retrying 6months later. Calcium d glucerate improved my erections and ejaculation power.

When looking at PFS I noticed the pattern that comes often that is. Methylation,homocysteine,NADPH and H.pyroli.
Where they fit together(Asked AI for a connection)
H. pylori → inflammation + poor B12/folate absorption → impaired methylation → elevated homocysteine → oxidative stress → increased NADPH demand → glutathione depletion.
H.pyroli causing inflammation increased NADPH demand but also stops calcium de glucerate from doing its work fully because:
H. pylori (possible) → Depletes B12 + folate → Loop 2 cannot break → Raises Hcy → Loop 3 worsens → Increases beta-glucuronidase → Loop 1 harder to break → Passive gut reabsorption → CDG partially undermined → NADPH depletion via NOX2 → BH4 synthesis impaired → Glutathione depleted
u/Drwillpowers is this making any sense?

My mother is suffering everyday, any safe interventions to lessen the pain? I got her on OMEGA-3 to lower inflammation.