No character can defeat Kashimo without needing advanced RCT to regrow limbs
What the title says. Regrowing a limb is a rare feat among sorcerers in JJK and Kashimo is exceptional at removing them. Losing a limb means weakened CQC and no domain (with the sole exception of Satoru Gojo ofc) which means you're a goner. (unless you're Sukuna)
All battles in JJK have h2h combat and sooner or later Kashimo will be able to use his surehit to at the very least, remove a limb or worse.
And for the "domain diff" argument, no one opens their domain as the first attack in a battle. It's completely out of character for anyone to lay out their ultimate attack which leaves them extremely vulnerable afterwards,
However if one does start off with a domain, then congratulations you still have to fight a full strength Kashimo in your domain with no surehit due to HWB.
So would it be safe to say that unless a character can regrow their limbs in battle, they're finished against him?