u/Basketweave82

I had a DVT and PE 2 years ago. Barely survived. Found out I was Protein S Deficient and since then we have assumed it's on our mother's side, though haven't confirmed it yet.

My mother (68) suddenly developed really bad muscle pain in the back of her left thigh and it's radiating down the leg and she's having trouble walking. She already has arthritis, varicose veins, neuropathy, her muscles are bunched up in other leg too for awhile but this time her pain is severe. We were thinking it's due to one of already existing conditions. But today she asked if it might be a DVT. Painkillers are having an affect. I remember they didn't do me any good with my DVT pain.

Also her foot and calf is not swollen, thigh not swollen.It is painful to touch but no redness.

I'm freaking out when she brought up DVT and can't sleep now lol. Can there be a DVT with no foot swelling? We're going to an orthopedic today but wondering if it's better to get a colour Doppler done first and fast to rule out DVT.

I used to be the person who could fall asleep as soon as my head touched the pillow. Always.

But as B12 deficiency and symptoms of intense fatigue, balance issues, muscle weakness increased, so did insomnia. I feel so tired but when I lie down I can't sleep till 2 or 3 am. If I nap during late afternoon, I can't get up even 2 hours later. Tried reducing sleeping during daytime but still can't fall asleep at night.

Just started hydroxo injections. Does anyone know how long this can last?

I only got my 2nd injection today, hydroxocobalamine 1000mcg E3D (I have CKD so I'm spacing it every 3 days).

But it's happened both times that 4 or so hours after the injection, I got sudden intense stomach pain, face sweaty and had to rush to the bathroom. Lasted less than 10 minutes and then I was fine.

Did anyone get anything similar? I have PA, methyl injections gave me horrible panic attacks, can't use cyano as it affects kidneys. I'm hoping these symptoms will go away with time? Because there's nothing else I can do but bear it.

I have early stage CKD (creatinine stays around 1.4) on no treatment. I don't have any symptoms either.

Diagnosed with PA. I started with sublinguals 1500mcg methylcobalamin. Only took this for 6 days but my pee got really smelly and urinary frequency increased. Also made me shaky and jittery.

Is it possible for this to be from the B12? My injections are still being delivered (hydroxo) so I'm wondering how I might react to them.

My nephrologist has gone out of town for a month so I'm left on my own on this.

I took 3 methylcobalamin injections 2 years ago and they gave me panic attacks where I felt I was dying.

I have early CKD with always elevated creatinine. I just read that cyano involves the kidneys? Is this true?

I also have an enlarged heart muscle (HCM) and am on anticoagulants (Xarelto) for life after a pulmonary embolism.

I went to a doctor and they said I "could" start methylcobalamin injections. Just once a week. Take 2 and see how it goes. But he didn't listen when I said they didn't suit me.

Which form is safest for a person like me? I'm getting no support from doctors and family thinks it's all in my head as well.

Please clarify what it means. Do I first get B12 levels up? Do I take lesser folate than usual?

I asked AI again just to be sure and it gives the same reply - not to take folate till B12 is up. Help?

Anyone here from India detected with Pernicious Anemia? What is your treatment plan?

Duloxetine 20mg daily. Taking B12 injections every 3 days. What should be done?