Negative signatera + CEA! What's next?

Hi, my mom was diagnosed with stage IV rectal cancer in March 2025 with liver, lymph node, and later bone metastases. She completed 6 months of FOLFOX, had surgery to remove her primary tumor in October 2025, then unfortunately developed more liver metastases and a bone metastasis in January 2026. She was treated with FOLFIRI, later added Avastin, and received SBRT to the bone lesion.

Her latest PET/CT shows both liver tumors have continued to shrink (1.4 × 1.2 cm → 1.1 × 0.8 cm and 1.3 × 0.9 cm → 0.9 × 0.6 cm), no PET-active disease, no active lymph nodes, and the bone metastasis remains inactive. Her CEA is now normal and Signatera is negative.

At this point, should we push for liver-directed treatment (ablation/surgery/etc) or a treatment break with close surveillance? Has anyone been in a similar situation, and what did your team recommend? Posting here because it seems like I'm experiencing an error on Colontown and can't post anything...

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Burden Kahn mansion wedding timeline

Hi! I'm getting married at the James Burden Mansion and trying to work through our vendor load-in timeline. We've unexpectedly run into some potential additional venue costs related to setup timing, so we're trying to understand what a typical timeline looks like at this venue. If anyone got married there (or worked a wedding there), would you be willing to share roughly what your timeline looked like? Specifically:

- What time vendors started loading in

- When rentals/catering/florals/decor arrived (and in what order)

- Guest arrival & ceremony time

We're at the top of our budget and it'd be super helpful to see what has worked for other couples/vendors!! Thank you :)

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u/BowlerAdventurous158 — 14 days ago

Where can I try on Sau Lee dresses?

Hey! I'm looking at Sau Lee for a potential reception dress and they look gorgeous online...but I'm wondering if theres anywhere in NYC i can try them on before purchasing. Some styles I like are on sale, but the return policy is store credit only for discounted items. Thanks in advance!

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u/BowlerAdventurous158 — 1 month ago

I've been in branding for about 8 years as a strategist (now director) across several agencies. I am reworking my website and want a page to list awards for several projects that have been recognized. I've snooped a few of my former colleagues' websites and it seems like some of them have listed awards on their website for things outside their core focus (e.g., design director lists award for naming strategy even tho he only worked on the vis id, etc). So I'm wondering what is the rule of thumb here? Do we put all awards for the same client we've touched? Or is that messed up? TIA.

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u/BowlerAdventurous158 — 2 months ago