Negative signatera + CEA! What's next?
Hi, my mom was diagnosed with stage IV rectal cancer in March 2025 with liver, lymph node, and later bone metastases. She completed 6 months of FOLFOX, had surgery to remove her primary tumor in October 2025, then unfortunately developed more liver metastases and a bone metastasis in January 2026. She was treated with FOLFIRI, later added Avastin, and received SBRT to the bone lesion.
Her latest PET/CT shows both liver tumors have continued to shrink (1.4 × 1.2 cm → 1.1 × 0.8 cm and 1.3 × 0.9 cm → 0.9 × 0.6 cm), no PET-active disease, no active lymph nodes, and the bone metastasis remains inactive. Her CEA is now normal and Signatera is negative.
At this point, should we push for liver-directed treatment (ablation/surgery/etc) or a treatment break with close surveillance? Has anyone been in a similar situation, and what did your team recommend? Posting here because it seems like I'm experiencing an error on Colontown and can't post anything...