MTX, Biologics, Family Planning,?
Hi everyone, I’m hoping to hear about your experiences and gain some perspective.
I’m 34F, and I’ve been dealing with recurring anterior uveitis since 2020. I'm also HLAB27 positive, but have not been officially diagnosed with any other autoimmune condition. My rheumatologist says I may have an inclination towards Ankylosing Spondylitis but it is not present yet. I've only had 3 episodes so far but my episodes have become increasingly aggressive, requiring me to step up from Prednisone to stronger corticosteroids - Durezol/difluprednate. Because I’m worried about the long-term side effects of relying solely on steroids, I recently saw a uveitis specialist who recommended moving to DMARDs, specifically Methotrexate (MTX).
This has been a lot to process because my husband and I were just starting to consider family planning. The specialist advised that he wants me on a 2-year treatment plan and that I absolutely cannot be pregnant during that time. This news has really halted our plans. We are also currently exploring egg freezing options.
I’m hoping to get some input from those who have been through this:
- How did you respond to Methotrexate? Did you find it manageable? Any specific side effects?
- Is MTX typically a lifelong medication, or have many of you been able to stop after a certain period?
- How did you navigate family planning while on these medications? Were you able to pause MTX and start trying for a baby after 2 years? Did you experience any lingering fertility impacts?
- I’m planning to ask my doctor about switching to pregnancy-safe biologics instead of MTX. Has anyone successfully advocated for this switch, or had a similar experience navigating insurance/doctors to get on a pregnancy-safe alternative?
Any advice, personal stories, or questions you suggest I ask my specialist would be so appreciated. Thank you!