Noise issue update
Hopefully this helps someone who has similar issues.
EDIT: I don’t believe it is an issue with the QC. I have made good progress in mitigating the issue.
My primary set up is QC->Mixer->Monitors. A major issue I identified was having the mixer too hot when trying to achieve desired volume. Having a hot signal there would amplify the bad noise when making adjustments to QC IO settings when trying to get a good signal. Because of this, a disproportionately weak signal was being pushed hard via monitors/mixer not the QC.
After configuring my levels I’ve been able to isolate the issue to amp blocks particularly high gain/low headroom amp models. My approach to dealing with the remaining noise is to implement a side chained gate, input gate, and a gate after the amp.
I still feel a little unsure about everything because I’d imagine that QC presets usually don’t give people these issues right out of the box. I am new to amp modeling though and there’s lots to learn. I’ve always been a plug and play or set and forget kind of player with traditional amp/ pedal board set ups, but I think the QC truly shines when you build and configure your own presets.