Positive anti-CCP but negative RF and ANA — anyone have similar results?
Hi, all! I’ve recently received some labs from my first rheumatologist appointment and am curious if anyone has had a similar bloodwork pattern, particularly early on in the process of being evaluated for RA?
I recently had a rheumatology workup and my results were:
Anti-CCP: 8.5 (positive; normal <3)
Rheumatoid factor: negative
ANA: negative
ESR/sed rate: 40 (high; normal <20)
CRP: 5.1 (slightly high; normal <5)
Anti-Smith, dsDNA and SSA/Ro: negative
I know bloodwork alone can’t diagnose RA, and I’m following up with my doctor. I’m mostly curious about other people’s experiences.
For context, my appointment was prompted by my ortho history - I’ve had 7 shoulder surgeries, including the world’s first 3D printed clavicle - and I’ve recently found out my rotator cuff is torn again. Before any decision to undergo another procedure, I wanted to be sure I covered all my bases and made sure there wasn’t some sort of underlying inflammatory condition contributing to my complicated history.
Did anyone here have a positive/low-positive CCP but negative RF and ANA when they were first being evaluated? If so, did you eventually receive an RA diagnosis, and what ultimately helped confirm or rule it out—symptoms/exam, repeat labs, ultrasound/MRI, etc.?
I’d especially love to hear from anyone whose results looked similar to mine!