Overall themes of the show, and the questions the show forces us to ask about this potential future [discussion, question]
Spoilers!
Something Pantheon forces us all to consider is the philosophy behind identity, what makes us "us", and what makes someone a person at all. I love how open ended the show leaves that, but there's something the show indirectly asks its audience that I don't see a lot of people discuss. So I'm making my own post about it to see what people think.
Is it worth it for people to give up their original lives, to essentially give birth to a whole new species - whose lives have the potential to be so much better and more meaningful than the lives of embodied humans? And whose existence could potentially threaten whatever remains of humanity that chooses to remain embodied? This question does assume some things, like the view that uploading your consciousness kills you and creates a digital version in your place, which from what I see of discussion on this sub to be the dominant view.
One thing we see in the show when the humans and UIs are in conflict is that there's a divide in how the UIs view embodied humans who never intend to upload. Many still see them as their "family" in a sense, a lot seem to see them as a hindrance to whom they only extend moral consideration because they understand that humans are sentient, previously having been one themselves. I don't think it's a stretch to say a lot of UIs end up viewing the humans as unevolved or less than themselves.
If any of this technology ends up being feasible at all, the implications and potential impacts they could have on humans and UIs in a real world scenario could be a lot darker than what we end up seeing in the show. It is doubtful that every human would end up downloading even if this becomes a possibility one day, just as we see in the show. Which could leave remaining humans in much more vulnerable positions overall.
Edit to add: for clarity and just to restate the question and main focus here: Is this technology one that we could implement now or in the near future in such a way that wouldn't most likely end in disastrous consequences? Is it worth the potential sacrifice of human lives for a new type of life? Not assuming the actual capability to implement the tech, but the implications it would have for humans - embodied or UI.