u/DP_Downund3r

I developed sudden onset cfs 6 years ago while working a ransomware recovery effort. We were required to work 7 days a week, long hectic hours. Towards the end I developed a viral infection. It was not COVID. I suspect it was a reactivation of the Epstein-Barr virus triggered by extended chronic stress. I have the markers. It literally was a very sudden onset of cfs. I collapsed after the last string of straight working days. I haven't been the sane since. For the first four years I relied on the healthcare system to help me. What a waste. Their stated strategy then, as is now, to rule out every possible cause before treating it. Basically I was a cash cow for many unneeded tests. I can't even get a list of all tests they want to run. Basically they are stalling. After four years of this my cognitive ability was fading. I was getting worse. I managed to keep my job by doing nothing outside of work other than resting for the next work day. I never got any advice from my doctors on how to manage the condition, much less treat it. My doctors didn't even know what pacing was. I finally took matters into my own hands. I started researching heavily. Right away I learned about D-Ribose, Acetyl-L-Carnitine and Ubiquinol CoQ10. These helped significantly. Over time, I found even these can trigger PEM so I started a balancing act of which days do I skip what supplement. But life was improved. I could walk more, but no vigorous exercise. Recently I came across a study showing promise. NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are both dietary supplements used as precursors to boost levels of NAD+, a critical coenzyme involved in cellular energy and metabolism that declines with age. My cfs seems to be caused by a disfunction of the mitochondria triggered by a post viral infection during a period of prolonged stress. I tried taking NADH orally to boost mitochondria function, but I saw no benefit. Research indicated that NADH is broken down in the gut, so it isn't beneficial. As the NMN + NR supplements are needed precursors to generating NAD+ I figured it was worth a try. Its been a little more than a week, but I've noticed much improvement over everything else I've tried. I sleep better, wake feeling more refreshed and have more energy throughout the day. I quit taking Acetyl-L-Carnitine and Ubiquinol CoQ10 as it was causing inability to sleep with the NMN + NR supplement. This has been the best I felt since the onset of cfs.