u/Dangerous_Flower_624

Has anyone had TG go up after starting Zepbound?

I’m 4 years out from papillary thyroid cancer and had a total thyroidectomy. My TG has been super stable for years, usually around 0.2–0.4.

I started Zepbound about a month ago, and my latest TG came back at 1.4. Not a huge number, but it’s definitely higher than my usual, so I’m freaking out a little.

I know it could be unrelated, and obviously recurrence is the scary thought. But the only other thing I can think of is that the first couple weeks on 2.5 mg were rough on my stomach, and I’m wondering if it messed with my levothyroxine absorption somehow. Maybe my TSH went up for a bit and pushed TG up? My TSH is normal now on labs, but TG hasn’t gone back down yet.

Has anyone else had their thyroglobulin rise after the first month on Zepbound or another GLP-1? Just trying to see if anyone has experienced something similar.

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u/Dangerous_Flower_624 — 17 days ago