triple-negative breast cancer recurrence with a high Ki-67 of 60-65%. My NGS report also showed TP53 and PTEN variants.
Hi everyone,
I’m posting on behalf of a 33-year-old woman mother of 5year little girl from India and would really appreciate experiences from people who have been through something similar.
Histroy -Diagnosis:
Triple-negative breast cancer (ER 0, PR 0, HER2 0)
Grade 3
Ki-67 around 60–65%
Initially diagnosed as Stage IIIC (T2N3bM0)
Previous treatment:
4 cycles Paclitaxel + Carboplatin
4 cycles Adriamycin + Cyclophosphamide
Right breast surgery + axillary node clearance
Pathology after chemotherapy: 0.8 × 0.6 cm tumour, 3/18 lymph nodes positive
Radiation: 60 Gy in 30 fractions
5 cycles Pembrolizumab (Keytruda) + Capecitabine
Unfortunately, a recurrent lump was found in the right breast in June 2026. Biopsy again showed Grade 3 invasive ductal carcinoma, ER/PR/HER2 negative, Ki-67 60–65%.
PET-CT showed an active lesion in the right breast and some right axillary/internal mammary lymph nodes. There is also a very small lung nodule described as indeterminate. Importantly, the PET report says there is no definite metabolically active disease elsewhere in the body.
The oncologist has now started Eribulin (Halaven) + Pembrolizumab (Keytruda) as second-line treatment. The plan is 4 cycles followed by response assessment. After about 3 cycles, they will reassess whether mastectomy.
She just started 3rd cycle . some amazing news: her latest ultrasound shows a wonderful response, and the tumor has already shrunk down to just 8mm! The plan is to complete this 4cycle and head straight to a mastectomy.she sometimes worry about the cancer coming back in the future, but she staying strong for her little girl.
Has anyone else with a similar mutation profile or high Ki-67 been on Eribulin and Keytruda? I would love to hear your long-term success stories and experiences.
Thank you all!"