▲ 6 r/AusTRT
12 months on TRT - Time to add E2 blocker?
36M on TRT through a clinic in Australia. Looking for experiences from guys who’ve had similar bloods/symptom patterns, specifically if I should consider adding a low-dose oestrogen blocker, anastrozole (clinic's recommendation based on latest bloodwork).
Started TRT due to:
- low free testosterone
- joint pain
- fatigue
- brain fog
- low motivation/libido
- poor recovery
Protocol progression:
- Started around 125mg/week test e split 2x weekly
- Felt strong physically, libido improved, but developed elevated anxiety/agitation
- Reduced dose progressively
- Tried 90mg/week and felt flatter: lower libido, less gym drive, lower motivation
- Now on 105mg/week split 3x weekly (0.14mL 3x/week Primoteston)
Current bloods:
- Total T: 29.1 nmol/L
- Free T: 834 pmol/L
- SHBG: 21
- E2: 211 pmol/L
- Hematocrit: 0.48
- Lipids/glucose/liver all good
E2 timeline:
- March 2025: E2 376
- December 2025: E2 295
- Latest bloods: E2 211
Current symptoms:
- Libido good
- Motivation/drive good
- Anxiety now mostly good
- Gym performance good
- No major water retention
- No nipple sensitivity/gyno symptoms
Only things I still notice occasionally:
- Maybe taking slightly longer to recover from training sessions
- Occasional moodiness/emotional sensitivity
Clinic is suggesting introducing low-dose anastrozole because E2 is above target, but I’m hesitant because I’ve read a lot of guys feel worse crashing E2.
Interested to hear from anyone who:
- naturally runs higher E2 on TRT
- stayed without an AI long-term
- or found symptom relief from a very small AI dose without hurting libido/mood.
Not looking for medical advice, just real-world experiences from others.
u/Dr_Poopy_butt_hole — 2 days ago