Not sure what is happening- pretty sure it’s a triple neg MPN
Ok all of this has been going on since Dec 2025 when I went to the ER for a massive migraine. Found out my A1C was elevated. Got a new PCP in Feb (diagnosed with Type 2 diabetes). Pretty sure I have a triple negative MPN.
41F, last 6 months have been really really bad, going in for a BMB tomorrow(Tuesday). I think my hematologist is trying to kick the can down the road since the diagnosis isn’t “easy”. I’m somewhat of a medical “unicorn” because I’m a natural redhead and some medical history (gallbladder surgery- took 3 years for someone to find my calcified gallbladder) and the way meds work on me isn’t “easy”.
Chest CT results:
Mild mediastinal and bilateral hilar lymphadenopathy in the chest, unclear etiology. These may be reactive secondary to infectious
or inflammatory process, or reflective of low-grade lymphoproliferative disorder.
Abdomen CT Results:
Slight hepatomegaly is present; Bilateral renal cysts are present. Mild prominence of the bilateral renal collecting systems is noted
Blood work:
02/17/26: WBC 11.9 K, hemoglobin 15.1 g/dL, platelet 351K
03/27/26: WBC 16.4 K, hemoglobin 15.2 g/dL, platelet 432K
04/03/26: WBC 17.3 K, hemoglobin 15.5 g/dL, platelet 422K
4/22/26: WBC 16.1k, MCHC 31.9g/dL; PLT 470k, RBC 5.31 10^6 u/L, ANC 11.7 10^3/uL, C-reactive protein .8 mg/dL, IG# .08, LY# 3.71
ESR mm/hr-38
Iron saturation % 13
Ferritin 57.4 ng/mL
05/07/2026: WBC 17.2k, MCHC 32.2g/dL; PLT 391k, RBC 5.45 10^6 u/L, ANC 12.22 10^3/uL, IG% .6, EO# .43, IG# .10, LY# 3.49
MPN panel negative for JAK2, MPL, CALR
FISH, CML/ALL, BCR/ABL translocation 9,22 interphase FISH negative
ANA negative
RF negative
peripheral blood flow cytometry normal
peripheral blood smear normal
Symptoms since December 2025:
Severe fatigue
Night sweats
Muscle pain
Weight loss
Loss of appetite
Ankle swelling
Headaches
Body aches
Medications since February 2026:
Oral antibiotics
IV antibiotics
Steroids
Monoferric iron infusion - has not helped at all so far (4 1/2 days in)