Experience with escalating to JAKi VS colectomy in ASUC?
Asking an actual gastro question amidst the sea of laymen neuroses...
Anyone had experience with stepping up to JAKi instead of colectomy for ASUC? Had a young patient, new diagnosis UC. Steroid induction failed, fulfilled oxford criteria, escalated to infliximab induction accelerated regimen. Also failed. Ended up proceeding to colectomy because ultimately guidelines don't suggest JAKi and we didn't want to delay further.
Of course, if he'd declined surgery, we would have offered JAKi. But given the small cases of ASUC to run sufficiently powered studies, there isn't much data.
Anyone had experience escalating to JAKi instead?
u/EastTry6940 — 11 days ago