u/Familiar_Athlete8411

I reckon this is an under considered effect of MT2. Since MT2 is non-specific and hits all the MCR receptors it is known to have an effect on the CNS - notably the upregulation of adrenaline release and response. The CNS stimulatory effect is part of the method of appetite suppression and effects on fat storage.

Anyway, I ran it for a few months at ~500μg a day - did get a bit tanned, and didn't really notice too many sides - however, this I believe was a false reality. Unbeknownst to me it was messing with my CNS - and it didn't show up until I went off TRT into a cycle, and the extra stimulation from that absolutely fucked my sleep and heart rate - which never happened before.

Since dropping the MT2 everything has calmed down, sleep is improving etc.. but this was not something I ever considered. It's a pain really since I'm the most pale person you can imagine lol, however, looks like MT1 may be better suited to me being specific to MC1R receptor which doesn't trigger the CNS and adrenaline responses that the others do.

Just a warning for anyone who might have a sensitive CNS - I spent ages trying to work out what the issue was because MT2 didn't give me sides - but pulling it helped dramatically.

Kind of know this is slightly against at the rules, but I wonder if anyone has had similar labs.

My FT3 and FT4 sit high, either at the top of or just beyond the reference range. But my TSH doesn't seem to drop in response (stays about 1.5-2).

Seemingly I have a number of subtle symptoms that would be associated with high thyroid hormones, for example disrupted sleep, ridiculous calorie intake requirements, a high or unstable heart rate, comtimuous jitters throughout the day, etc... my research suggests 2 things, RTH - which is genetic and everyone else in my family is fine, also doesn't typically present with symptoms, or abnormal TSH secretion, which also doesn't seem to make sense as I've actually had recent labs with TSH briefly responding to the high FT3 level (although the next test literally a week later it was back up) - it seems like the set point is just too high and subtly messing with me.

I've brought this up with a Dr but no one is particularly interested so I'm left a bit to my own devices here - I potentially have some data from a while ago that should imply mild thyroid suppression and I felt better, and recent data that suggests an increase in FT4-FT3 conversion and feeling worse (go on, go through my profile if you must, I'm using this account intentionally). But there's no real explanation for my labs and the existence of symptoms that would be associated with a hyperthyroid state - and I've already systematically ruled out every single other cause.