Title: Wegovy pill vs Foundayo: which looks better?
The UK weight-loss pill market has just become more interesting.
Foundayo was approved yesterday so now the Wegovy pill finally has some competition and hopefully Novo will reduce their prices, heres the thing, the two medicines are quite different. Firstly, Foundayo is not Mounjaro in tablet form. Although both are made by Eli Lilly, Mounjaro targets GLP-1 and GIP, while Foundayo targets GLP-1 alone. Based on their separate clinical trials, Wegovy pill currently appears to have a modest advantage for average weight loss:
Wegovy pill: 13.6% over 64 weeks
Foundayo: 11.1% over 72 weeks
I wonder if the quicker to average weight loss is due to the shorter schedule?
Foundayo among people who remained on treatment: 12.4% However, they have not been tested directly against one another. These figures give us a useful idea, but they do not prove that one will work better for an individual person.
Foundayo’s biggest advantage is how easily it should fit into everyday life, the Wegovy pill must be taken on an empty stomach with no more than 120ml of water. You then need to wait at least 30 minutes before eating, drinking or taking other tablets.
That may sound simple, but it can become inconvenient surprisingly quickly. Morning coffee has to wait. Breakfast has to wait. Other medication may have to wait. Miss the routine and you may end up reorganising the start of your day around one tablet. Foundayo can be taken at any time, with or without food and without limiting how much water you drink. For anyone juggling work, children, early starts, shift patterns or several other medicines, that freedom could be genuinely useful.
The less appealing part is the six-stage dosing schedule:
0.8mg → 2.5mg → 5.5mg → 9mg → 14.5mg → 17.2mg
There must be at least one month between increases, so someone starting at 0.8mg would need a minimum of around five months to reach 17.2mg.
You do not automatically need to reach the highest dose. If a lower strength is working well and remains tolerable, there may be no benefit in rushing upwards. Even so, potentially working through six different strengths looks rather drawn out, especially as prices vary between them.
The side effects will sound familiar to anyone who has used a GLP: nausea, constipation, diarrhoea, vomiting, indigestion and abdominal pain. Tablets must also be swallowed whole rather than split or chewed etc.
My early verdict is fairly simple:
Wegovy pill has the stronger trial result. Foundayo has the easier routine.
That convenience should not be treated as a minor detail. A medicine can look excellent in a clinical trial, but it still has to work around someone’s actual life. For some people, the freedom to take Foundayo whenever it suits them may matter more than a relatively small difference in average trial results. It's now authorised in the UK, but it is not yet available. We still need UK prices to be published.
Which would matter more to you: Wegovy pill’s stronger trial result, or Foundayo’s much simpler daily routine?