1. My perscription is 50mg. I do not work; I simply sit at my computer at home every day, using AI to learn about everything that interests me, and I enjoy it. Based on my medication log below, I have come to the following conclusions. 30mg is my titration/transition dose. 40mg is my optimal dose because it provides the best results and the longest effective duration. Therefore, once the 40mg efficacy drops, I do not plan to increase it to 50mg. Instead, I will take a drug holiday and then restart from 30mg. 50mg significantly increases the washout period my body requires. So my current plan is a repeating cycle of: 30mg - 40mg - break (less than a week) - 30mg. Based on your experiences, please share your opinions.

• 2. I have been trying to return to the long, effective 40mg periods of the first and second cycles through this repeating loop of 30 - 40 - break (< 1 week) - 30. However, it seems that the 50mg from the second cycle caused too high of a tolerance/accumulation in my body. Does this mean I might need a prolonged drug holiday to eliminate the accumulation from the 50mg? For example, a one-month drug holiday? Is it possible for me to ever get back to the 3-to-4-month effective 40mg cycles I experienced in the first and second cycles? (The 83 days of 40mg in the second cycle was shorter than the 118 days in the first cycle. This was not because the efficacy at the end of the second cycle's 40mg was unsatisfactory, but rather because I had more tasks to handle and actively chose to increase the dose to 50mg. In fact, the effective duration of 40mg was longer than 83 days.)
• 3. Why didn't I feel any improvement in efficacy after increasing the dose from 30mg to 40mg in my fifth and sixth cycles?

I’d really appreciate any response.

**Thank you all for your replies. You may find my way of thinking confusing, but I actually have ADHD combined with Asperger’s syndrome. That’s why I pursue extreme precision, which might come across as being overly nitpicky and stubborn.

Vyvanse Medication Log (Complete Version)

Cycle 1: Initial Exploration and First Golden Period (Clean System Baseline, Zero Burnout)

• 30mg (Cycle Start): June 6, 2025 — June 20, 2025 (15 days)
• Details: Initial starting dose. Felt good, considered about 85%-95% of optimal efficacy, extremely mild/smooth. After about 5 days (June 11), obvious tolerance or efficacy drop appeared (roughly 60%~70% efficacy). Because the doctor prescribed 30mg for 15 days, continued taking it for a total of 15 days.
• 40mg (Golden Thrust): June 21, 2025 — October 16, 2025 (118 days)
• Details: Entered the first stable period, consistently effective throughout. This stage represents 100% standard efficacy, slightly stronger than the 30mg period, not as mild. Towards the end of this stage, efficacy dropped significantly (roughly 60%~70% efficacy).
• 50mg (First Strong Push): October 17, 2025 — October 23, 2025 (7 days)
• Details: Voluntarily stopped due to strong PNS side effects (palpitations, chest tightness). Perceived efficacy was roughly ~90%, subjective effect likely lowered by side effects.
• 0mg (Cycle End): October 24, 2025 — October 29, 2025 (6 days)
• Details: First washout period, hoping to reset tolerance. Slept a lot during this time.
• Cycle Summary: 40mg is the golden sweet spot dose (longest duration); 30mg only had optimal effects for 5 days (over-titrated); 50mg had too many side effects, unwilling to tolerate.

Cycle 2

• 30mg (Cycle Start): October 30, 2025 — November 1, 2025 (3 days)
• Details: 30mg worked well, consistent with the previous 40mg, used only as a bridge/transition.
• 40mg (Stable Maintenance): November 2, 2025 — January 24, 2026 (83 days)
• Details: Entered the second stable period. Slight drop towards the end of the stage (roughly 80%~90% efficacy), but the feeling remained acceptable.
• 50mg: January 25, 2026 — February 15, 2026 (22 days)
• Details: Voluntarily increased dose due to needing to wake up early to drive father to rehab (sleep deprivation). Felt better than 40mg (110-120% efficacy, using the initial 30/40mg as the 100% perfect baseline), side effects similar to 40mg, without the strong reactions of Cycle 1. In the last 10 days (Feb 6-15), efficacy dropped significantly (70-80%), sharply declining 5 hours after taking the medication, feeling almost unmedicated.
• 0mg (Cycle End): February 16, 2026 — February 19, 2026 (4 days)
• Details: Forced washout. Crazy amounts of sleep + high protein, L-Tyrosine (1500mg twice), and Magnesium Threonate supplementation.
• Cycle Summary: Reconfirmed 40mg as the golden sweet spot dose.

Cycle 3

• 30mg (Cycle Start): February 20, 2026 — March 1, 2026 (10 days)
• Details: Perfect efficacy 100%. Very poor sleep for the first five days (dynamic alternate-day dosing; skipped medication when sleep was under 6-7 hours), took it daily for the last five days after sleep recovered. Perceived ~80% efficacy in the final days.
• 40mg: March 2, 2026 — March 16, 2026 (15 days)
• Details: ~Perfect efficacy 100%. On March 14, efficacy noticeably dropped/slipped (~60-70%).
• 0mg (Cycle End): March 17, 2026 — March 22, 2026 (6 days)
• Details: Medication washout.
• Cycle Summary: The effective duration of 40mg was drastically shortened compared to the first two cycles, and tolerance to 50mg also built up rapidly, causing anxiety.

Cycle 4

• 30mg (Cycle Start): March 23, 2026 — March 29, 2026 (7 days)
• Details: Perfect efficacy 100%, dropped to 70~80% after about 5 days.
• 40mg: March 30, 2026 — March 31, 2026 (2 days)
• Details: Adding 10mg did not bring an increase in efficacy, still at 70~80%, anxiety worsened.
• 30mg: April 1, 2026 — April 14, 2026 (14 days)
• Details: Dropping from 40mg back to 30mg actually caused a noticeable drop in efficacy (40-50%). From April 1-10, efficacy slowly rebounded to ~70%-75%, then maintained this level until April 14.
• 0mg (Drug Holiday): April 15, 2026 — April 21, 2026 (7 days)
• Details: Started washout on April 15. Initially very sleepy, could fall asleep quickly in bed with high sleep quality, excellent appetite. By April 18, stopped feeling sleepy, started having mild spontaneous excitement and motivation. On April 19, appetite decreased, became hard to fall asleep, and my brain started racing uncontrollably.

Cycle 5

• 30mg: April 22, 2026 — May 3, 2026 (12 days)
• Details: Skipped medication twice occasionally during this period. The first day felt similar to the earliest 30mg of Cycle 1 (85-95%), extremely mild, long-lasting. The peak onset was slower compared to the mainstream 100% efficacy stage of 40mg; previously, the peak was mostly 1-2 hours after taking the pill, but now the effect is still very average at the 2-hour mark, causing a lot of worry. However, it got better and better after 3 hours, peaking around 3-5 hours, extremely mild and stable, with a long duration. Towards the end, felt efficacy drop to 70-80%.
• 40mg: May 4, 2026 — Present
• Details: Increased dose to 40mg, felt no noticeable improvement in efficacy compared to 30mg.