Medicine in gelatine capsules - is there a difference in absorption if I open them up?
I have been prescribed ADHD meds which come in gelatine capsules but I’m vegetarian, so I’ve been opening the capsules and putting the powder into my morning protein shake (the leaflet in the packet says this is OK to do).
Today I wasn’t concentrating (see: ADHD!) and just swallowed the capsule whole. The meds have hit differently today - they feel way more intense than before. Everything else was the same: the dose, the time I took them, what I ate and drank beforehand, etc.
So my question is, how much difference does a gelatine capsule make to absorption? Gelatine dissolves in lukewarm water so I can’t imagine it surviving that well in warm stomach acid. Is there really a difference?