u/Healthy-Breath-8701

Okay, so I don’t do keto for any weight loss reasons. I do keto for mental health benefits and the fact that I am an addict by nature. This means that when I’m on carbs, i quickly start eating a jar of nutella per day (no joke), and I’m also prone to anxiety etc.

On keto, zero cravings, complete self control and dramatically reduced anxiety.

The only thing I have noticed is, that as I become more keto adapted, I lose the mental health benefits. I assume homeostasis, feedback loops etc.

I come off keto (and sadly struggle to get back) but when I do get back, the mental health benefits are profound again.

Leading me to want to understand if targeted keto or periodic non-sugar carbs are worth playing with.

I’m hesitant to even try it, because I just know how hard it can be if I fall into carb addiction. But, the mental health benefits when they come back are so fricken awesome.

Note: I can regain the benefits by taking exogenous ketones. But this also hits a wall a short time after using them. So I prefer to stay away from them. I have also tried to increase MCT (both coconut oil, and actual MCT and both have the same effect of working for a bit and then not)

No carb creep, I eat the same meals every 2 days.
Plenty of electrolytes.
I feel great, the diminished benefits doesn’t imply anything negative.

any guidance would be amazing!

Patient here, not seeking medical advice Seeking a discussion on the existing data, and any non-published data from clinical experience.

Quetiapine has a real risk of TD and metabolic effects. This appears to be dose dependent for TD and less so for metabolic.

Background:
I have been using Quetiapine 25mg for 3 months (insomnia) and let me tell you, best 3 months of my 35 years. Reliable sleep, I wake up calm and happy, my diet has improved, my exercise routine has gone from nothing to now doing yoga, and bike riding. My business is performing better. Life is wonderful!

I decided to come off Quetiapine last week. Had 3 days of insomnia, and now am getting sleep again. That said, I would like to go back on it perhaps in a week or two.

TD risk is unacceptable and if I had of known I may not have taken it.

There appears to be very little data on TD in doses of less than or equal to 25mg used regularly. Moreover, there appears to be no data on those same doses being used intermittently (2-3 times per week).

Question:
Is there any data or anecdotal reports of individuals having movement disorders present themselves after these low doses? Or after intermittent use?

Given the steep curve relating to the histamine blockade at these doses it’s known to be primarily a histamine blocker. However, there are some serotonin and alpha1 blocking effects as well and then perhaps still some d2..

Considering how quickly it unwinds the d2 blocking effects it feels like intermittent use would lower the risk substantially as the negative feedback loop wouldn’t be happening over sustained periods. That said there are reports of TD, but seemingly not enough to draw any serious conclusions.

Lastly, are there any drugs with similar profiles to Quetiapine without the risk of movement disorders?