u/Inner-Package2978

https://www.otsuka-us.com/news/otsuka-presents-positive-interim-phase-3-visionary-egfr-data-showing-voyxactr-sibeprenlimab

In conclusion, the present study demonstrated that rifaximin reduces the progression and the severity of IgAN observed in humanized mice (α1^(KI)-CD89^(Tg)) and showed that rifaximin might open a new therapeutic avenue for IgAN. However, more detailed research is required to establish the precise molecular mechanism involved and the exact role of microbiota in this pathway.

I’m sharing this article because some people take probiotics to improve their IgA nephropathy, but caution is needed: if these probiotics contain Akkermansia muciniphila, they could potentially make things worse.

https://www.science.org/doi/10.1126/scitranslmed.adl6149