u/Jedc14

Hi, my wife and I (both 40) just got the results for the first trimester combined screening and it shows High Risk (1:20) for Down Syndrome. In week 10, we had done a NIPT and it had shown low risk (less than 1:10000) for T21. We don't know how to feel about it. The doctor told us to trust the NIPT more, but we can't avoid being worried. Is there any similar experience? How did it end?

We're also confused about the screening values. I thought that 1:20 means a 5% probability of T21, but at the same time the doctor says that the rate for False Positives in High Risk diagnosis is below 15%?? Do you know how these values work?

Thank you all in advance