u/Jennyyyyyy22222

MTF with PSSD

I am mtf and have been on feminizing hrt for 6 years.

When I was a teenager my dermatologist put me on Isotretinoin up to a 80mg/ daily dose. I did this for long courses the longest one being two years.

I think this somehow messed up with my system.

Symptoms:

1- severe genital numbness - I can only sense and get pleasure from the tip of my organ. There is absolutely no sensation or pleasure from being touched on the rest of it.

2- Premature ejaculation and Post Orgasm Illness. Once I organism I am literally knocked out for at least a day. Anhedonia kicks in, and it’s extremely hard to get off the bed or do any task. I recently learned to take hydrocortisone before or after sexual encounter with my partner which helps significantly with the energy and crash but not with the anhedonia

3- After orgasm, this state lasts for roughly 3 days or 4 then slowly I start to recover though only fully at about a week

What helped me a lot is progesterone rectal { I get extreme amount of energy immediately upon the insert, the anhedonia disappears almost fully and I feel like myself again, though the effect only lasts for about 5 hours max once the capsule gets metabolized, If I don’t redose the crash continues. I have a problem with progesterone because it certainly converts to androgens in my body because afterwards I get significantly increased of body hair and some masculanization.

I am looking for alternative things to try, has anyone tried something else that works?

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u/Jennyyyyyy22222 — 10 days ago

Retatrutide (MtF)

Can anyone share experience with recycling weight using retatrutide? I know that Dr Powers is a big fan of Trizepatide; However Reta is new and also acts on the Glucagon receptor to promote lipolysis in white fat, fatty-acid oxidation and especially hepatic fat burn.

Had anyone tried it? And is this additional benefit; on paper; good or bad?

(ps I know Reta is not yet FDA approved)

reddit.com
u/Jennyyyyyy22222 — 15 days ago