Lc-MSMS Shimadzu
Machine: LC-msms Shimadzu 8060
Problem is we are seeing bad controls over the course of the run but not every analyte. We have done some flow through and optimization. With no big increase.
We run two different methods using two different columns.
The Second method uses APCI and one analyte on there is fine in the curve but by the end CCV it's just barely passing QC check. The Mobile phases are water and methanal.
Method 1 is ESI and there are a few on it that are not great. Mobile phases are Water and Methanal with 2mM NH4F.
The samples are acidified.
We just replaced the optic system and Q1 was cleaned. Should I clean Q3?
I have attached a tune. The one on the left is after we replaced the optic system and the one on the right was the engineer during a PM. I am just not seeing any benefit from replacing the optic system parts.
