u/No-Floor9464

Anyone else get chronic hives on Truvada/TDF-FTC?

Started PrEP 2+ years ago. ~6 weeks in, started getting urticaria triggered by heat and exercise (cold room = fine, hot outside or working out = hives). Has gotten gradually worse over 2 years, not better. Switched from Truvada to generic Tenvir-EM recently, no change.

Weird thing: had IV fluids in an ER once for unrelated reason, and the urticaria disappeared for 2 weeks before coming back.

Is this a known PrEP side effect that people deal with? Did antihistamines help? Did anyone resolve it by switching to Descovy?

Thanks.