NIPT T21 Positive, 37yrs, NT 2.5mm…CVS or Amnio?
Hi everyone,
I’m currently 12w5d and feeling quite overwhelmed trying to decide between CVS and amnio after a high risk NIPT result for Trisomy 21.
I’m 37 years old. My NIPT came back high risk for T21 with a fetal fraction of 12%. From what I understand, my PPV is estimated to be fairly high because of my age and fetal fraction.
I’ve also had my NT scan and the measurement was 2.5mm at 12w5d. From what I’ve been told/read, this seems borderline rather than clearly enlarged, and otherwise the scan has not shown any obvious major abnormalities so far.
I also have a posterior placenta, which I’ve heard can sometimes make CVS more technically difficult depending on positioning.
One of the hardest parts of this decision is that if diagnostic testing confirms T21, we would choose to TFMR. Because of that, I feel a huge pressure to make the “right” decision regarding testing and certainty.
I’m struggling with whether to proceed with CVS soon, or wait a few more weeks for an amnio. Part of me wants answers as quickly as possible, but part of me is anxious about confined placental mosaicism (I know very very rare) and wonders if amnio would give more certainty straight away.
I know the results will more than likely be positive for T21 but I lean toward waiting for the amnio for a definitive answer before making any major decisions— but the waiting feels very difficult.
I would really appreciate hearing from anyone who:
- had a high risk T21 NIPT with a relatively normal NT
- had a posterior placenta and experience with CVS
- chose CVS and was happy with that decision
- waited for amnio instead
- had experience with confined placental mosaicism
- had similar measurements/results and can share outcomes
I’d really value hearing real experiences while I process everything.
Thank you.