u/Other_Knowledge6225

I have been happy that I’ve tolerated Dayvigo with zero side effects. But the other side of that is that it works erratically. Occasionally I fall asleep well after taking it, but most nights I don’t. I have tended to need high doses for every sleep med I’ve tried. I’ve looked at the way the max dose of 10 mg was derived, and there was benefit found for some people at 15 and 20 mg over 10 mg. But side effects were greater, so the 10 mg recommendation was a balance. I have no side effects but insufficient benefit, so it seems to me that I’m a good candidate for trying the higher doses.

Last night I took 15 mg, and I slept. I’m not going to be overly reactive to that data point, but I sure feel better today. We will see whether that benefit is sustained.

Anyone else try higher than officially recommended doses?

I’m always struck by the many posts describing it’s taking multiple nights to benefit. I get it if that involved observing and needing to increase the dose. But otherwise, DORAs work by directly blocking orexin-mediated wake signaling rather than requiring receptor adaptation or neurotransmitter remodeling, so there is no physiological reason for a delayed onset.

And that was my experience. Dayvigo didn’t work better for me over time. It’s always been the same. There is no “build-up” with this drug, and there’s no theoretical reason there should be. It’s not like a benzo or an SSRI where you need receptor up- or down- regulation which may take days to weeks.

Just saying