u/Other_Knowledge6225

I’m always struck by the many posts describing it’s taking multiple nights to benefit. I get it if that involved observing and needing to increase the dose. But otherwise, DORAs work by directly blocking orexin-mediated wake signaling rather than requiring receptor adaptation or neurotransmitter remodeling, so there is no physiological reason for a delayed onset.

And that was my experience. Dayvigo didn’t work better for me over time. It’s always been the same. There is no “build-up” with this drug, and there’s no theoretical reason there should be. It’s not like a benzo or an SSRI where you need receptor up- or down- regulation which may take days to weeks.

Just saying