u/Patrickplus2

CONTROL OF NEUROTRANSMITTER RELEASE

SCRAPPER is a type of enzyme called a ubiquitin ligase. It attaches ubiquitin tags to the presynaptic protein RIM1, marking RIM1 to be broken down by the cell's proteasome.[1] This role is why SCRAPPER is described as a "destroyer" protein.[3]

RIM1 is a protein at the synapse's active zone that helps control neurotransmitter release. By keeping the amount of RIM1 under control at the active zone, SCRAPPER helps regulate how easily synaptic vesicles release neurotransmitters. In mice that lack SCRAPPER, neurons become overly active and build up higher levels of RIM1. These effects can be reversed by restoring SCRAPPER or by reducing RIM1 levels.[1][2]

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