u/Practical-Pain5151

▲ 4 r/UCTD+1 crossposts

Anyone dealt with numbness in feet/lower legs while on leflunomide?

Has anyone else dealt with numbness as a side effect of leflunomide? A year ago, I added leflunomide to my regimen (400 mg Plaquenil), and it worked really well for me. I recently developed numbness in my feet and lower legs, so I’ve been taken off of it- still on Plaquenil. Waiting a month to see if side effects/numbness resolves, and will likely switch to another medication.

Background, I have UCTD, mostly lupus-like symptoms - rashes, skin inflammation, joint pain, fatigue. I’ve been on 400 mg Plaquenil for almost 5 years. Not asking for a diagnosis, just curious if anyone else has ever had numbness like this.

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u/Practical-Pain5151 — 11 days ago