Misleading PR
Hi all, I just looked into the Brayer study.
The SLS phase 2 headline says there was a 64% immune response rate, but I realized that's a bit misleading because it was for CR1. Tsirigotis presentation also made it look like those numbers were for CR2, but the actual brayer paper shows that only 20% (2/10) of the CR2 cohort actually had an immune response.
I know the brayer study is messy but it makes me imagine what else they could have been a bit misleading with. Like the enrolment population?
It also makes me question the authenticity of Dr Tsirigotis, as a physician and researcher I’m pretty sure he would have been aware of this.
Here are all the links:
Tsirigotis in sellas presentation: https://youtu.be/nCtrZavKCuM?is=AkTi42x94rsJOHzc
Sellas immune response PR: https://ir.sellaslifesciences.com/news/News-Details/2025/SELLAS-Life-Sciences-Announces-Positive-Outcome-of-Interim-Analysis-for-its-Pivotal-Phase-3-REGAL-Trial-of-GPS-in-Acute-Myeloid-Leukemia/default.aspx
Brayer 2015 Study CR2/ Others: https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.24014
Maslak 2018 Study CR1: https://pubmed.ncbi.nlm.nih.gov/29386195/