u/SunnyDay7272

Hi all! I (48f, diagnosed with ET 4 years ago) started on a super low dose of Besremi (50 mcg every 2 weeks) a couple of months ago. I initially started on Hydrea, but it didn’t lower my platelets. I then tried Pegasys, which worked to decrease my platelets but my liver couldn’t handle that (AST and ALT numbers went sky high). So now I’m on the Besremi; my doctor was optimistic since you can take much smaller doses than you can w Pegasys. But… bloodwork today shows that my liver is being affected again. Both numbers are about triple what they should be.

My question is, has anyone else experienced this liver issue with interferons? Did any adjustments to dose or frequency help? I don’t know what other medication options I have…