Bad reaction after 1st Daratumumab (shot)
Hi all. I was recently diagnosed and just had my first infusion appointment on Thursday. I’m on the DVRD regimen- started Thursday with subcutaneous injection of Dara and subcutaneous injection of Velcade. I was fine until I got home later and started having chest tightness, wheezing, sneezing, headache, etc. I was instructed to take more Benadryl (I took 25mg as a pre-med beforehand). That helped and Friday I woke up fine. Friday evening I suddenly developed chills, body aches and low grade fever. I also noticed the injection site where I got the Dara had spread in size, it was red and purple and quite large. I head to the ER as they had told me I needed to since my fever was 100.7 . I was admitted and got antibiotics and fluids through IV for the past two days. Thankfully I’m better and the reaction site isn’t red anymore. They said I had an adverse reaction to the Dara. Anyone else have a similar experience? I’m supposed to go back this week to have another infusion but I’m really nervous and almost traumatized to even get Dara again. I still have to talk with my oncologist about what she thinks about trying it again. Just wanted to see if there are others out there with similar experiences. Not fun way to start out treatment