Can’t get a diagnosis. Positive ANA 1:160
Hi everyone, male 36 yo here.
My story begins 4 years ago, post covid infection I started having athralgias and pain in my fingers.
I already had Hashimoto, so I began running tests to understand what was happening.
My initial results were ANA+ 1:80 and everything else was negative, except for 1 time positive LAC and borderline SSA-ro60 (1.0 - nv: <1.0)
This has been my only symptom for the last 4 years, while I still were running yearly checks. My ANA increased to 1:160 with homogeneous pattern, then 1:160 but with speckled 6 months ago. LAC was back negative everytime, same for SSA)
Last month I got a flu, or Covid, and I started having pain in my knees, exclusively when moving. They would get red and hot after a long walk too.
Along with this, stiffness and pain in my shoulders, dorsals, arms, elbows areas. Muscles too are quite stiff, like day post workout or when slept in a bad position.
I did run again my usual checks last week, and pretty much nothing changed, except for ana pattern that now has also nucleolar alongside speckled.
Now i’m worried about scleroderma.
ENA screening negative, profile aswell for SSA, SSB, SCL70, CENP, etc (the Classic 6 panel).
In the last 4 years, a round of different rheumas, no one could give me any diagnosis, saying that my isolated positive ana were due to hashimoto.
Now I have new symptoms, but blood tests didn’t change much.
Everything still negative. ESR 2, CRP 0.14. Normal c3, c4, normal CPK and aldolasi.
All other autoimmune panels negative too (checked for rheum factor, CCP, anca, DSDNA)
HLAB27 also negative.
Also MRI on knees came back normal.
Never had any Raynaud, rashes or whatsoever. But I developed Acne Rosacea recently.
Suggestions? I’m kinda lost.