u/Vincent6m

Abstract

Purpose : To quantitatively evaluate symptomatic vitreous opacities (SVOs) (floaters) in human eyes using an investigational non-contact Scanning Laser Ophthalmoscopy (SLO) and Optical Coherence Tomography (OCT) imaging platform.

Methods : Adults presenting with symptomatic vitreous opacities (floaters) were imaged with a novel non-contact AI-guided investigational SLO/OCT device in two independent clinical trials. The system simultaneously captured SLO sequences and volumetric OCT scans. A combination of manual and automated image analysis was used to localize the SVOs within the vitreous body and to quantify their size, opacity, morphology, and location relative to the retina.

Results : A total of 238 eyes from 135 subjects were analyzed. Both male (39.7%) and female (60.3%) subjects were enrolled, with the majority aged 65 years and older. Across both studies, a total of 1045 SLO and 966 OCT images were acquired, SVOs were visible in 943 SLO (90.2%) and 779 OCT (80.6%) scans. Opacities were quantified based on their size, opacity, and morphology; as well as location relative to the retina and motility during imaging.

Conclusions : Study showed that this novel non-contact AI-guided SLO/OCT imaging platform proved to be a useful tool to capture and quantify floaters. Findings provide the first in vivo quantitative database of floater morphology that suggests a positive correlation with patient-reported perception of floaters. These findings fill an existing gap in the understanding of floater morphology, providing a foundation for objective evaluation of floater severity and guiding future image-based treatment strategies to enhance patient quality of life.

This abstract was presented at the 2026 ARVO Annual Meeting, held in Denver, CO, May 3-7, 2026.

Abstract

Purpose : To compare the post-operative complication rates between 25-gauge and 27-gauge pars plana vitrectomy (PPV) for patients with symptomatic vitreous floaters.

Methods : The practice management system at Retina Associates of Cleveland, Inc. was used to acquire data on patients who received PPV for symptomatic floaters between January 2020 and March 2025 using CPT codes. Patients without a minimum 3 months of follow-up were excluded. 25-gauge and 27-gauge designation and incidence of post-operative complications of endophthalmitis (E), retinal detachment (RD), or vitreous hemorrhage (VH) were recorded. The complication rates were compared using a two-proportion z-test.

Results : 940 eyes were included in the study. Of which, 821 underwent PPV using a 25-gauge system and 119 underwent PPV using a 27-gauge system. 38 patients (4.63%) undergoing 25-gauge PPV developed post-operative complications (1 E, 18 RD, 19 VH) compared to 5 patients (4.20%) undergoing 27-gauge PPV (1 E, 3 RD, 1 VH). Using a two-proportion z-test, a z of 0.21 was compared with a p value of 0.84 to support a lack of a statistically significant difference in the results.

Conclusions : The complication rates between patients undergoing 25-gauge and 27-gauge PPV for symptomatic floaters differ slightly (4.63% and 4.20%, respectively), but were not found to be statistically significant. It is plausible that smaller wounds would lead to fewer complications, but this was not supported in this study. However, a limitation was the substantially smaller sample size of cases performed with the 27-gauge system (based on surgeon preference). In the future, this study would benefit from a larger number of patients and more balanced sample sizes between the two gauges used.

This abstract was presented at the 2026 ARVO Annual Meeting, held in Denver, CO, May 3-7, 2026.

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