u/bawheid

I have a somewhat rare and indolent non-Hodgkin lymphoma called Waldenström's macroglobulinemia (WM). When I needed treatment I had R/Benda in 2016 and it worked very well.

Now my numbers and symptoms indicate that I need another round of treatment. However, because R/Benda is known to cause DNA damage, there's a school of thought that it shouldn't be repeated. Research papers suggest though that, if it was sufficiently long ago and was well-tolerated and worked, it warrants repeating the R/Benda treatment.

I'm going to get my bone marrow tested for DNA abnormalities as well as testing for the CRCX4 and MYD88 mutations relevant to WM to check if the BTKs (the brutinibs) will be effective as an alternative treatment to the proposed R/Benda regime.

Any input or insights gratefully received.

I had R/Benda in 2016 and it worked very well.

Now my numbers and symptoms indicate that I need another round of treatment. However, because R/Benda is known to cause DNA damage, there's a school of thought that it shouldn't be repeated. Research papers suggest though that, if it was sufficiently long ago and was well-tolerated and worked, it warrants repeating the R/Benda treatment.

I'm going to get my bone marrow tested for DNA abnormalities as well as testing for CRCX4 and MYD88 mutations to check if the brutinibs will be effective as an alternative treatment to the proposed R/Benda regime.

Any input or insights gratefully received.