u/cakebaker28

Hi guys, I'm a newbie at this, please help if you can! We need to lyophilize a water-soluble compound, basically, we mixed it into a second liquid compound so the first compound would be encapsulated and give better results for our purposes. What I need to know: we have to freeze this before it goes into the lyophilization machine, but we were told to freeze it first in a normal freezer, then move it to a -80°C freezer, and only then send it to the lyophilizer. Is this accurate? If so, how long should it stay in the normal freezer before going to -80°C, and how long should it stay at -80°C before going to the lyophilization machine? Is there some kind of protocol for this? I tried to find something and couldn't find an exact one. Thank you!!

Hi guys! I hope this is the right place to ask!

I'm working on my first systematic review.

We're currently at the title and abstract screening stage with about 3,400 articles. Today I spent 3 hours screening and got through around 300 papers. At this rate, I'm looking at roughly 34 hours of screening... and that's just for this phase. We're following the PRISMA guidelines.

We're using the free version of Rayyan. Is it normal for screening to take this long? Do you have any tips or workflows that help you get through papers more efficiently? I'm not looking for AI to do the screening for me, since I'd still need to verify every decision myself.

Right now, I'm searching for keywords based on our exclusion criteria (e.g., terms that clearly identify irrelevant studies) and excluding those papers as I screen. I'm not sure if that's the most efficient approach, though.

Any advice would be greatly appreciated. Thanks!!