Sorry if this has already been answered in some other Fate material, but wouldn't there be some mages who will actively impede the progress of science to slow the weakening of Mystery?
So if Mystery is needed for magecraft to be effective, and the progress of science reduces Mystery, then shouldn't a group of people that are as morally corrupt as Mages attempt to do whatever they can to impede science? Like actively encouraging superstition, eliminating scientists, making public distrustful of science, etc.