u/coatoctopus

What is this?

He doesn't do this often and it's always random. Like he could be resting and will just start but once I comfort him he stops. He's a cocker cavalier mix and our old full cocker never did this so I don't know if it's a breed thing or a dog thing.

u/coatoctopus — 3 days ago

I started "Stelara" and it's still not working

I started Yesintek (a bio similar to Stelara) about nine weeks ago and it's not doing anything.

Some backstory: this is my third biologic since being diagnosed in May 2024 and I was on Entyvio from June 2025 to like January of this year because my doctor made me wait the full six month period for it to start working and it never started working. My symptoms just got worse and worse. So he ordered a colonoscopy at the end of January which they couldn't even finish the procedure because my colon is so inflamed and then I did the calprotectin test and my score came back over 4000 which is the highest it's ever been because at this point I've essentially not been on a working medication for almost a year – next month will be a full year. I share this because you'd think he would have a little more urgency in prescribing something that would take less time to work but anyway. After the colonoscopy I started an eight week course of prednisone and had my first induction infusion of this medication while still on prednisone.

When I started this new biologic he said it would take 4 to 6 weeks to start working and then when I got off prednisone and it hadn't started working within that timeframe he then told me it would take at most 8 weeks to start working. Well eight weeks came last week at my injection training appointment and I shared with the nurse that nothing was working and I still have crazy symptoms and that my doctor said it would take eight weeks and it's been eight weeks so what's going on. And she said it would take another month for it to start working because the injection was the second dose.

I get that the medication needs to build on itself but he said eight weeks and she said give it another month. For it to maybe start working? Like how I was supposed to wait six months for the Entyvio to maybe start working and it never did? I am beyond frustrated and I want to trust their plan but at the same time, what this medication is just gonna start magically working at the beginning of June when my next injection is the beginning of July? That doesn't make any sense. If it was just gonna magically start working because it's building on itself, to me it should've started working already. Even just a little bit but it's not working at all.

TL;DR: Anyway I'm obviously beyond frustrated and had to let out a little rant but my question is should I wait until June to see if it kind of starts working or should I message my doctor now? Because what if I message him now and insist on trying something else but then what if I'm wrong and this one would end up working if I gave it until June?

What was your experience with Stellara?

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u/coatoctopus — 8 days ago