Testosterone dropped 60% since starting Blueprint - likelihood they are related?
Question in title, but additional background below.
35 year old male, have been in excellent health my entire life.
Began partial Blueprint stack in January 2026. I take the following four products: Blueprint Essentials, AntiOxidant Capsules, NAC+Curcumin+Ginger, and Ashwagandha.
Beginning in February, began noticing classic symptoms of low T. Loss of muscle definition, decrease in athletic performance (noticeable drop in strength, and ~20% drop in average Peloton output), lack of energy, and fewer nighttime erections.
Got blood work done a week ago and compared to my June 2025 labs:
- Total T: 674 to 283 (-60%!)
- Free T: 120 to 53
- Sex Hormone Binding Globulin: 42.7 to 31.56
- TSH: 2.11 to 2.107 (unchanged)
- Vitamin D: 58 to 63
While my previous labs were 6 months prior to starting BP, I'm pretty sure T didn't start dropping until shortly after using BP since I didn't notice symptoms until then (and check out before/after pictures from November 2025 and April 2026 below). Diet and exercise have not changed. Cortisol is low-normal (10.5ug/DL). All other biomarkers came back excellent and stable (even improved on some like HbA1c going from 5.2 to 4.9). Side note: my Vitamin B12 was off the charts (1252 pg/mL), likely from Blueprint Supplementation.
The complicating factor is that I moved from CT to Puerto Rico at the same time as beginning BluePrint, so there are a host of factors besides the supplements which could be contributing (the heat, environmental toxins, the water here, etc.).
AI says there is strong evidence that Curcumin and Luteolin – in Blueprint stack - could contribute to reduced T but I don’t know whether to believe it. In any case, stopping all Blueprint supplements.
Here’s what I looked like in October 2025:
Here’s what I look like now: