De-labelling 'treatment resistant schizophrenia' patients who were never psychotic?
I've recently passed a few of these patients off to my attending for full reformulation.
It seems that they got a schizophrenia diagnosis while under the influence of drugs or a cognitive impairment, and antipsychotics thrown at them. The antipsychotics didn't work (or worse, work 'a little bit' because their behaviours 'improve' from being sedated all the time), so they got more antipsychotics thrown at them, and some of them go on clozapine.
These people end up on bizarre combinations of 3+ oral + depot antipsychotics +/- clozapine, 'residual psychotic symptoms' and a high burden of side effects which inevitably get more medications thrown at them.
Of the patients I've had reformulated so far, one was pseudopsychotic secondary to severe BPD with erratic behaviour and impulsivity labelled as 'disorganisation', one had previous episodes of drug-induced psychosis (but no primary psychotic illness) + aripiprazole-induced impulsivity + had ongoing perceptual disturbances from HPPD, and one had ASD + a cognitive impairment + a prolonged grief reaction which could not be distinguished from actually perceiving dead loved ones due to the impairment.
All improved markedly once delabelled, deprescribed, and put through intensive psychotherapy (though behaviours initially worsened as sedating medications were removed).
How frequently do you see this kind of presentation in your practice and what are your thoughts? Leaving this question quite vague as I'm keen to hear an open discussion with whatever clinical gems people feel inclined to drop.