Relief - at least for now
I was diagnosed with RLS in 2021 and put on pramipexole - which worked for almost two years. Then it started to augment and my legs would start to itch badly and I started to sleep very poorly until I took more. I got off pramipexole (painful to get off) and just tried to cope. Discovered if I pedal for 15 minutes or do 250 stairs they would settle down - usually for at least an hour or two. But I got to the point where I would get up 3 to 5 times a night - just trying to sleep in between- not sustainable. Then I tried pregbalin which only seemed to work a few times for me - and it wasn’t helping me sleep like the doctor claimed it would. Fast forward to 2026 - I started to see a homeopathic who did a GI test. He saw some unusual zonulin numbers that indicated i had some form of leaky gut. I knew that I had leaky gut at one time and that gluten likely caused it. I had been off gluten for several years and thought my gut was better. At any rate my homeopathic prescribed me with larazotide - which tightens the junctions in your gut ( my interpretation). Bottom line it has been life changing - i have virtually no RLS anymore. I can’t tell how many times I have laid awake scouring these archives for anything to help. I have no idea if this can help anyone else but it has certainly helped me - with no side effects that I can tell - and I wanted to at least share my experience.