Unknown Significance Detected
My father (57) got diagnosed with AML M1 last year Aug 2025. After the 1st chemotherapy combination of decitabine + venetoclax he is in deep remmission till now
6 genetic mutations got detected in with 4 know clinical significance and 2 unknown significance
4 known significance
Dnmt3a
Phf6
IDH2
asxl1
2 unknown significance (VUS)
Runx1
IDH2
We took last bone marrow biopsy 2 weeks before and results showed all 4 known significance are not detected and less than 1% but the 2 unknown significance are same as like it from the start. It still remains with 50% both
Even MRD is negative and Fish test is also negative
Now doctor has advised either to increase the dose of decitabine or opt for Bone marrow Transplant because of the unknown significance still remains with same percentage
Me and my mom both are confused either to increas the dose or continue with the existing chemotherapy decitabine (38mg) 5 days + venetoclax 14 days
Also, for the past 10 months he is very active and no side effects. Even after every chemotherapy recovery is also good . Currently he is very normal as how he used to be 2 years back
Are those unknown significance really a threat for relapse or these mutations are there in his DNA from birth?