u/psilent

So I was looking around for a place to share this, and this seems like a good spot. I've been trying to help my wife grow, and did a ton of research into the mechanisms of macromastia, adapogenisis, and hormonal trends for breast growth. I came up with a two part solution that seems to have been showing some results. The amount of data i can gather is limited by how annoyed she gets with the process, but here are the results so far

date |Bust |Underbust |Waist |low hip
4/15/26 |39.5 |36.25 |39.625 |41.5
4/25/26 |39.875 |35.5 |null |null
5/9/26 |41 |35 |null |null
5/18/26 |40.5 |34.5 |null |null
5/27/26 |40.75 |34 |33.7 |40.55

The two treatments I'm doing are massaging in a acetyhexapeptide-38 and volufiline cream into her breasts, and an aminophylline cream everywhere she doesn't want fat. I apply these two creams around 3-5 times a week.

acetylhexapeptide-38 and volufiline both act on preadipocytes to stimulate their differentiation into adipocytes. Human data is limited on both unfortunately, but the studies that do exist show limited but statistically significant breast growth in 2 month trials. additionally, acetylhexapeptide-39 is an inhibitor for the same sites that 38 is an agonist, and 39 shows a strong blocking effect of adipogenesis which does strengthen the case for 38 somewhat. I don't even have direct access to these studies, and have been relying on third party reporting of what's in them so i wont link that here.

aminophylline is a b3 receptor memetic and encourages lipolysis in adipocytes. Essentially it causes fat to be released as glycerol and free fatty acids. This actually has a lot of good data behind it, and has been around and used safely since the 80s. I believe its popularity is only limited by the fact that it provides no significant weight loss on its own, it merely encourages fat to be released from specific subcutaneous areas preferentially. It also has no impact on visceral fat, so its only useful for sculpting purposes. https://pmc.ncbi.nlm.nih.gov/articles/PMC9978326/

By combining these two treatments, we are freeing up glycerol and fatty acids from unwanted areas, and creating the blood serum environment to encourage adipogenesis. We are then preferentially encouraging the preadipocyte differentiation in breast tissue, so its more likely to re-store this fat than other areas of the body. Used separately, I do not believe either effect would be as strong, as there's no excess glycerol to be stored as triglyceride in breast adipocytes (unless you're gaining weight) or take advantage of the signaling to create new adipocytes from acetylhexapeptide-38 and volufiline. Without the adipogenesis encouraged by those, aminophylline is somewhat effective at slimming subcutaneous fat but studies show its most pronounced effects were during a period of weight loss, as the fat will not return to the same areas but instead be used for energy.

Preparations: I found a cream containing acetylhexapeptide-38 and a 100% volufiline serum, and combined them in a way to create 5% volufiline by volume. I also added oleic acid to 2-5%, as this serves as a skin penetrating element allowing long chain peptides to penetrate the dermal layer and reach subcutaneous fat. olive oil is 60-70% oleic acid so its not as scary as it sounds, you can use that.

For the other, Amilean is available commercially and is useful as is. Its penetrating element is actually destroyed by oleic acid so dont do anything to that one.

Disclaimers: Obviously this is a single persons results, and I have only my own analysis of the available research to rely on. If someone tries a similar protocol please be careful and stop if you experience any irritation or ill effects. While these are all commercially available products, and act locally, addition of skin penetrating elements may change their behavior. Additionally, the primary mechanism by which fat volume is gained is the expansion of existing fat cells, not adipogenesis. I would expect this method to work less effectively on women with less starting breast tissue. She doesn't like to weigh herself either so I don't know if she has lost weight during this (though i expect she has from the measurements) It also has no impact on breast epithelium (glandular tissue) which is dense breast tissue and the primary driver of size in macromastia. Probably a good thing though as growth there is associated with increased breast cancer risk.

Oh the ratios for the breast cream were 120ml of the a-38 cream linked below, 7ml volufiline, 13ml olive oil.

If you do do this, take detailed data and let me know! id love to hear about it.