u/redingreenout

I’ve had AIH since November high Bilirubin up to 540 (now down to 33) and ALT high as 3330 down to 130 now back up to over 500. My bloods continue to be volatile and I’m living in misery with chronic diarrhoea. I’m wondering if anyone else is on a similar dosage as me?
I was put on steroids (Prednisolone) started at 30mg now down to 10mg a day but they don’t seem to be having any effect. I’m wondering if that dose is too low should I ask my doctor to increase or not bother?
They have discussed me taking a powerful immune suppressant called RITUXIMAB it’s very expensive and apparently I would need to sign a consent form due to some risks attached to it. The doctor said it would put my AIH liver disease into full remission but I am concerned. Again has anyone taken this medication?
Thanks for reading

So I’ve been unwell for 8 months woke up one morning last November and noticed I was looking yellow it took 7 months for my bilirubin to get down to 29 from 445. ALT enzymes started at over 3000 spent 3 weeks in hospital released in December 2025. Things were going well then in March everything went awol bilirubin and ALT sky rocketed so ended up being sent to a transplant unit at Addenbrokes Cambridge. Stayed a month released after tacrolimis and Mycophenolate protocol.
I managed to get everything down to a not so dangerous level but last 3 weeks ALT keeps rising now at 410 compared to 150 in May. Doctor has now put me back on steroids which caused me issues when I started them last year. I had a fibroscan last month which showed cirrhosis compared to no cirrhosis showing in January 2026. I’m at my wits end with this disease which I just can’t seem to get under control even the doctors are mystified why these drugs are not working as they should be. Is there any drug alternative to my current protocol that could help me get this under control that I can ask my doctor for?