u/science-pls

Sharing manufacturing info from Meamo Labs on their Jeunetique Exo Exosome based healer product.

Size: 2 vials (6mL +100mg), 1 box (6mL+ 100mg 5 vials each)

Vial Volume: 100mg, 6ml

Main Ingredients: Atelocollagen, Cellular Growth Factors, Exosomes, PDRN, Peptides

Course of Jeunetique Exo treatments: Jeunetique Exo is designed to be used as part of a structured treatment approach. Initial visible changes may be observed within 1–2 days as minor swelling subsides, while continued treatments aim to support ongoing improvement in overall skin quality.

What's Inside: Each pack has 2 vials (6mL +100mg), 1 box contains 5 packs

How to store MEAMO Jeunetique Exo/Precautions for safe storage and use of MEAMO Jeunetique Exo:

• Store vials away from heat sources and open flames, in a cool, well-ventilated place at room temperature.
• Do not expose the vial to direct sunlight.
• Storage temperature should not exceed 100°C (212°F).
• Once opened, the vial should be stored in the refrigerator at a temperature of 5-100C for no more than 7 days.
• Make sure the vial is always tightly closed.

Video is from Dr. Derrick Phillips, he addresses a few reasons on why hyperpigmentation may not be improving.

Post copy from his IG:

>If your hyperpigmentation isn’t improving, it’s usually because of one these reasons:

• inconsistent sunscreen use
• not treating the underlying cause (such as acne or eczema)
• using the wrong active ingredients
• over-exfoliating and triggering more inflammation
• using the wrong treatment for the type of pigmentation
• expecting results too quickly

Pigmentation takes time to fade, even with the right treatment.

Consistency, correct diagnosis and patience make the biggest difference.

The U.S. Food and Drug Administration (FDA) has granted 510(k) clearance for Dermalogica’s PRO Pen Microneedling System as a Class II medical device.

This authorization enables the company to market and distribute the PRO Pen in the United States beginning in 2026.

“I am excited to have led the team responsible for FDA 510K Clearance of Dermalogica’s new PRO Pen Microneedling System. The updated design represents a true milestone in Dermalogica’s expansion into Medical Spas and follows closely behind our highly successful Exobooster LactobacillusExosome Treatment Serum. I want to thank our scientific team and our clinical partners at our parent company, Unilever (UL) for their support and guidance,” says Robert J. Bianchini, PhD, Vice President of Technology and Development at Dermalogica, in a news release.

Their IG post:

>Meet the next evolution of microneedling.

Our new FDA cleared Pro Pen takes skin treatments further, enhancing precision to support skin renewal, refine texture, and visibly reduce acne scarring.

And another:

>A milestone for the industry ✨ The PRO Pen Microneedling System is here!

Advancing safety, quality, and professional confidence in microneedling procedures, we’re proud to bring the industry our newest FDA cleared PRO Pen device while staying true to who we are at our core. A company deeply committed to skin health and to empowering the power and expertise of the professional.

The PRO Pen Microneedling System is a microneedling device and accessories intended to be used as a treatment to improve the appearance of facial acne scars in adults aged 22 years and older. Please refer to the PRO Pen Instructions for full safety information, indications, contraindications, and device performance details.

Simple explanation of how a provider does it. Thought seeing it might be helpful.

There's always lots of discussion on the topic of molecular weight and HA. Figured I'd share some resources on medical literature on low-molecular weight HA.

The purpose of this review was to explore the current science and utility of LMW-HA in clinical dermatology and provide an update on its use.

A PubMed search from 2003–2023 on LMW-HA was conducted to evaluate LMW-HA’s utility in clinical dermatology.

>Key Points

1. This paper provides a comprehensive review of low molecular weight hyaluronic acid (LMW-HA) and its emerging role in dermatology. While hyaluronic acid’s utility is well-established across various medical fields, LMW-HA’s unique properties, such as its antimicrobial effects and ability to penetrate the skin more effectively than its high molecular weight counterpart, present new avenues for clinical applications.

2. This scoping review synthesises a wide array of small but significant studies that highlight LMW-HA’s potential in treating conditions such as wound healing, post-procedural care, and ageing, as well as its promise in cosmetic dermatology.

3. By providing an up-to-date exploration of LMW-HA’s dermatologic uses, this paper serves as a foundation for future research and underscores the importance of continued investigation into the safety and efficacy of LMW-HA. As dermatologists seek novel treatments for common and challenging skin conditions, LMW-HA offers an exciting, well-tolerated option that may improve both medical and aesthetic outcomes in certain conditions.

>Results: Identified applications of LMW-HA in medical dermatology included treatment of acute and chronic wounds, rosacea, scars, and seborrhoeic dermatitis. Cosmetic applications of LMW and hybrid HA included treatment of skin ageing, enlarged pores, and skin laxity, as well as enhancement of skin hydration. Topical LMW-HA administration promoted healing after cosmetic procedures, chemical peels, and ingrown toenail surgery. Studies of topical and oral LMW-HA demonstrated adequate safety, and newer techniques of administration, such as needleless jet injection, are available.

>Conclusion: Exploration and understanding of the properties and benefits of LMW-HA are key to translating its usage in the clinical setting. Basic scientists and dermatologists have achieved substantial progress over the past two decades, and several applications of LMW-HA in dermatology were identified. Additional advantages of LMW-HA are worth exploring.

Disclosure: Schlesinger is a consultant and/or investigator for Abbvie, Allergan (an Abbvie company), Galderma, L’Oreal, Senté, and HTL Biotechnology, outside of the submitted work. The other authors have declared no conflicts of interest.

Get Glowing Skincare is running a Memorial Day Sale, starting today!

21% off with code SCIENCEPLS

This lasts through the 27th.

Video is from Meamo Labs

Post copy:

>All Hollywood stars seem to be talking about one molecule right now - NAD+.

>Why? Because the decline of NAD+ is directly linked to the aging process. This molecule plays a crucial role in cellular energy production, DNA repair, and tissue regeneration.

As we age, NAD+ levels naturally drop - leading to fatigue, dull skin, and reduced firmness.

Scientists, including Dr. David Sinclair from Harvard, describe NAD+ as a key factor in longevity. That’s why many public figures and biohackers reportedly include NAD+ infusions or injections in their routines.

Wanted to share some regenerative medicine news.

The company has multiple avenues of bioregeneration as well in wound healing, aesthetics, oral health, 3d bioprinting, and animal health!

I found out about them through their aesthetics news. Conexeu or CXU is being developed as a collagen-based ECM scaffold intended to help restore the missing structure and support a more restorative environment for the tissue.

More info can be found at Conexeu.com. and The press release is here.

>Important Notices (from the site)
All cited studies [1]–[11] are preclinical findings generated from in-vitro models, animal models, or both, and [12] preclinical company data. Animal physiology differs from human physiology, and these findings are not predictive of clinical performance or safety in humans. None of the cited studies evaluated CXU™ specifically in breast tissue reconstruction; the breast reconstruction program represents the design-intent application of the underlying CXU™platform, and supporting evidence in breast-specific preclinical models is being developed by the Company.

>Conexeu’s BIO-REGENERATIVE ERGONOMICALLY ARCHITECTED SMART TISSUE™ (B.R.E.A.S.T.™) is an investigational medical device candidate. Safety and effectiveness have not been established. It has not been submitted to or reviewed by the U.S. Food and Drug Administration. Limited by U.S. federal law to investigational use.

>CXU™ is a medical device candidate in preclinical development and is not cleared or approved for marketing in the United States or any other jurisdiction.

>IMPORTANT NOTICES: CXU™ is a medical device candidate in preclinical development. It has not been submitted to or reviewed by the U.S. Food and Drug Administration. Safety and effectiveness have not been established. See Forward-Looking Cautionary Statement.Terms such as 'next-generation,' 'advanced,' 'innovative,' and 'bioregenerative' reflect the Company's assessment of its technology relative to existing approaches and are not intended as representations of regulatory status, clinical performance, or guaranteed commercial outcomes. CXU™ is an investigational medical device candidate. Safety and effectiveness have not been established. See Forward-Looking Cautionary Statement.

This is a small but intriguing case report (published in 2025) suggesting that microneedling with topical 3% salmon PDRN may improve facial hyperpigmentation. It is not strong enough to establish efficacy, but it gives a reasonable rationale for larger controlled studies.

Sample size is only 2 people and there's no control group. That means no reliable estimate of effectiveness, no subgroup insight, and no way to separate treatment effect from natural fluctuation, lighting, skincare changes, sunscreen use, or regression to the mean. And microneedling alone can improve texture and PIH in some patients, so I wouldn't use this as evidence, but rather an indication of where research is being targeted and will go. And also preliminary research is interesting for developing protocols.

Study Protocol
The necessary equipment and materials for the MN procedure included face wash soap, a MN tool (Dr. Pen®), a microneedle cartridge with 12 needles, topical anesthetic cream (EMLA®), sterile water, a 0.9% sodium chloride solution, topical antibiotic (gentamicin 0.1% ointment), medical gloves, and PDRN Salmon 3% in a 1cc syringe.

A full face microneedling (MN) treatment was performed, followed by the application of PDRN Salmon 3%.

The treatment consisted of two sessions spaced 21 days apart, with a post-treatment evaluation conducted at 6 weeks from the baseline (3 weeks after last treatment).

Study Technique
Deeply cleanse and disinfect the face to prepare a clean face for the treatment. Apply numbing cream for 30-40 minutes. Disinfect the entire face using alcohol swabs. Adjust the needle depth (between 0.5mm to 1.5mm) based on the target area. PDRN Salmon 3% was applied to the skin surface. Glide the pen across the skin to create controlled micro injuries and enhance serum absorption. During the PDRN application, pinpoint bleeding may still be visible on the skin surface. Afterward, use sterile gauze soaked in a sodium chloride solution to compress the patient’s face for 15 minutes, followed by cleaning with more sterile gauze. Note: this is verbatim from the study, not medical advice. Sharing for educational entertainment purposes only.

Study After Care
After the procedure, the patient was advised to apply gentamicin 0.1% ointment twice daily for three days and apply SPF 50 PA ++++ sunscreen each morning. Additionally, the patient received maintenance instructions for facial hygiene, avoiding face rubbing during washing, refraining from using night cream, and protecting against direct sun exposure during outdoor activities (e.g., using an umbrella or hat).

Meamo has a tiered sale on Meamo Labs products.

Cart total $100+ is 10% off
Cart total $200+ is 15% off
Cart total $500+ is 20% off

And an additional 15% off with the subs code.

Sale lasts May 19th - 27th Korean Time. Code is SCIENCEPLS

Link to pdf is here.

NCTF ® 135 and NCTF ® 135 HA are injectable medical devices which bear the CE Mark (CE0297). This brand has decades of clinical research and published data behind them.

Each box contains: 5 x 3ml vials of NCTF® 135 HA

Hyaluronic acid concentration 5mg/ml.

NCTF (New Cellular Treatment Factor) made by Fillmed Laboratories, is a popular, non cross-linked HA skin booster and meso solution that is designed to revitalize dull skin, intensely hydrate, and smooth fine lines. Rather than adding structural volume, it deeply nourishes the skin and helps promote natural collagen and elastin production.

The formula features 59 active ingredients: 

• Hyaluronic Acid: Hydrates the skin from within and restores a natural glow.
• 12 Vitamins: Stimulate vital cell functions.
• 24 Amino Acids: Aid in protein creation (like collagen and elastin).
• 6 Coenzymes: Catalyze biochemical reactions in tissue.
• 6 Minerals & Other Agents: Protect against free radicals and support cellular health

A standard aesthetic protocol typically consists of 3 to 5 sessions. 

Sharing the summary of safety and clinical performance sheet.

>This Summary of Safety and Clinical Performance (SSCP) is intended to provide public access to an updated summary of the main aspects of the safety and clinical performance of the device. The SSCP is not intended to replace the Instructions For Use as the main document to ensure the safe use of the device, nor is it intended to provide diagnostic or therapeutic suggestions to intended users or patients.

>The following information is intended for users/healthcare professionals. Following this information there is a summary intended for patients.

CC has English.

The creator of the protocol and prominent aesthetic trainer, Brenda Terra Zimmer, was officially invited by Korean biotech scientists to present this specific framework to the global medical community after proving how effectively it regenerates brow tissue. The protocol was widely introduced at medical conferences (the AAHRS and KIMES congresses in Seoul).

Post Caption translated to English:

>EXOBROWS PROTOCOL™
A new eyebrow care category.

>Thin, weakened brows and faded brow lines are no longer just a makeup concern.
Eyebrows are an important structural feature that completes a youthful and defined facial appearance.

>ExoBrows Protocol™ is
a new brow care protocol that combines ASCEplus HRLV with professional treatments such as microneedling, laser procedures, and RF microneedling.

>✨ Brow density care
✨ Brow line care
✨ Post-procedure environment care
✨ Healthier, fuller-looking brows
✨ A new category beyond ordinary brow serums

>This is no longer an era of simply drawing eyebrows on —
it’s the era of managing brows through exosome science.

>ExoBrows Protocol™
Powered by ASCEplus HRLV.
Regenerative Aesthetics for Brows.

My interpretation of the protocol.

Because the footprint of the eyebrow is incredibly small compared to a full scalp, a traditional scalp dilution will just run down the face and be wasted.

One vial of ASCE+ HRLV lyophilized powder (which contains 10 billion pure exosomes and 0.05% biotin) is reconstituted using 1 ml to 2 ml of sterile saline or (they list PRP so other booster.) Recon is gently swirled to maintain the structural integrity of the extracellular vesicles.

Eyebrow follicles sit shallower in the skin dermis than scalp hair follicles. If you go too deep, you risk permanently scarring or damaging the eyebrow's fragile dermal papilla cells. The needle depth is strictly between 0.5 mm to 0.75 mm maximum. This depth is chosen specifically because it targets the follicular bulge, which is exactly where dormant brow stem cells reside.

Before the liquid is fully applied, the provider uses a tight, cross-hatch microneedling pattern over the brow. This physically creates a pathway so the liquid exosomes can actually penetrate the hair roots. It's reco'd to trickled drop by drop onto the brows as the microneedling device passes over the area 2 to 3 times. The complete protocol requires a baseline course of 3 to 5 total sessions spaced exactly 2 to 4 weeks apart.

As of now, if you want more information on the protocol it's only available through training webinar**.**

Manufactured by ExoCoBio, ASCEplus HRLV is a premium exosome therapy designed specifically for scalp and hair restoration. It is widely used for both men and women experiencing androgenetic alopecia (pattern hair loss) and telogen effluvium. 

The creator of the ASCE+ HRLV exosome line, officially recognizes and co-markets the specialized "ExoBrows Protocol" developed by top international clinical trainers (such as Ms. Brenda Terra Zimmer) who pioneered utilizing the hair growth serum specifically for eyebrow regeneration and microblading scar repair.

Post caption:

>ExoBrows™ ASCEplus HRLV is a new exosome eyebrow care protocol designed to support fuller, healthier-looking brows using **ASCEplus HRLV** with advanced aesthetic procedures such as microneedling, laser, or RF microneedling.

>By delivering exosome-based bio-signals to the eyebrow area, ExoBrows helps revitalize weakened follicles, improve the skin environment, and create a more natural, dense, and youthful brow appearance.

>**A new category in beauty: exosome eyebrow aesthetics.**

Sharing another guide from Dr. Pen. This is a microneedling depth guide from them.

Imo this is a fairly conservative guide. Most facial areas are kept at 0.25 – 0.5 mm, only the fuller cheek area goes up to 0.5 – 1.0 mm and the sensitive/high risk zones (eyes, nose, lips) stay very shallow. These depths appear designed for minimizing injury risk, reducing downtime, supporting mild collagen induction, and are safer use for a wide range of skin types.

The correct depth also depends heavily on needle sharpness/cartridge quality, speed/stamp technique, skin thickness, technique, treatment goal (collagen induction vs acne scars), etc. This is for educational content only and is not medical advice.

I'd imagine they are purposely being conservative because of the at home vs professional device territory. The FDA does not publish approved depth for home use, but the key cutoff from cosmetic to medical is over 0.3 mm. Over that becomes medical depths and professional territory. The FDA has also explicitly stated it has not authorized any microneedling medical devices for over the counter sale so they probably need to be cautious in marketing. Recommending higher depths that could be interpreted for personal use could raise flags on their product distribution.

Although this is a microneedling sub, I think skin health, aging, aesthetics, and regenerative medicine are all part of a larger picture. And the best results come from combined modalities. I will continue to share all things and everything microneedling, but wanted to also share parallel topics and related studies.

The paper says retinoic acid, the active retinoid signal, caused reversible changes in mouse skin. It decreased the fast-cycling epidermal compartment and expanded the slow-cycling compartment. It also says both stem cell populations were pushed toward differentiation, and some remaining fast-cycling clones biased toward the slow-cycling lineage. When the retinoid was discontinued, the skin reset to what it otherwise would have been. 

This video is from dr.beibei.dermatology on IG.

Post copy:

>Stem cell or stem cell adjacent tech are all the rage in skincare, but actual skin stem cell research tells us that one of the most potent modulators of stem cell biology within bathroom cabinets is tretinoin (retinoic acid or ATRA). This study published in this months JIDJournal demonstrates how this works using lineage tracing experiments. Although this is not a human study, it provides key data regarding mammalian stem cell biology that informs our understanding of human skin.

Since a lot of us order from international vendors, I thought I’d make a quick guide because global tracking can look confusing if you’ve never dealt with it before. Your package is usually fine, it’s just moving through multiple postal systems.

Most delays are normal and don’t automatically mean your package is lost or there is an issue.

Start With the Original Tracking Number
Most vendors will send

• national postal systems (Korea Post, Royal Mail, La Poste, etc.)
• EMS
• UPS
• FedEx
• DHL
• K-Packet
• CJ Logistics
• Hanjin
• Lotte Global Logistics
• YunExpress
• 4PX
• Cainiao
• SF Express
• Yanwen
• USPS-linked international shipping
• regional logistics carriers
• export forwarding companies

The tracking may not update normally at first, especially during export customs. Early tracking updates are often limited while the package is waiting for export processing or airline transit.

Best Universal Tracking Sites
These work better than most carrier websites because they combine multiple shipping systems:

• 17Track
• ParcelsApp
• Postal Ninja
• PackageRadar

They often show the original carrier, transfer carrier, destination carrier, export scans, customs status and processing, and local handoff info.

Common Tracking Statuses
Shipment information received / Shipping label created / Pre-shipment = Label created, package may not physically move for a few days. The carrier may not have scanned it yet.

Processed through export facility = Leaving the origin country.

Handed to airline / Departed country of origin = Usually the longest quiet period. Could be in transit for days to weeks.

Arrived at destination country = It hit customs/import processing.

Inbound into customs = Normal. Doesn’t automatically mean inspection problems.

Processed through facility ISC = Moving through international sorting.

Released from customs = Cleared and moving to local delivery.

Tendered to delivery service provider = Local postal carrier has it now.

Your Package May Get a NEW Tracking Number
This often confuses people, but is super common with international shipping.

A package may:

• start with one carrier overseas
• transfer to another carrier domestically
• receive a second/local tracking number

The original tracking may stop updating once it reaches your country. Universal trackers usually reveal the new local tracking number and that will now show updates.

Typical Delivery Timelines
Obviously depends on customs and shipping method, but generally:

• Express courier: ~3–10 days
• EMS/ePacket: ~1–3 weeks
• Budget shipping: ~2–6 weeks

Holiday periods and customs backlogs or delays can add extra time.

Don’t Panic During "No Updates”
International tracking often goes silent during:

• export customs and processing
• airline transit
• customs intake
• carrier handoffs

A package can sit with no scans for 5–10+ days and still arrive normally.

Red Flags
Things that actually do or may indicate an issue:

• Returned to sender
• Held by customs for an extended period
• invalid tracking after 2+ weeks
• carrier says “delivered” but no package
• no movement at all after 10–14 business days

Always screenshot

• order confirmation
• tracking page
• payment records
• shipping insurance (if applicable)
• vendor policy

Makes disputes way easier if needed.

Hope this helps!

I noticed that there are lots of discussions on how to address the under eyes and wanted to share this paper.

It's obviously a small sample size and we need larger, randomized controlled trials to validate these findings and compare the efficacy of VAMP. Plus would love to see different protocols tested, FSTs, follow up timelines, and histological data or more objective measurements, but it's interesting preliminary research.

EXOXE Exosomes are developed by REGENBOGEN Biotech with its primary source as amniotic fluid. They are derived from mesenchymal stem cells (MSCs). These exosomes are known for their high purity and are rich in growth-promoting factors.

Here is a link on Scribd and one that's easier to download.

Info from Scribd:

>Exosomes are highlighted for their strong regenerative effects, aiding in skin issues such as whitening, wrinkles, and inflammation. The document discusses the benefits of amniotic fluid-derived stem cells, emphasizing their safety and effectiveness in regenerative medicine. EXOXE products are presented as superior exosome treatments, backed by clinical research demonstrating significant improvements in skin absorption and collagen production.