u/towngrizzlytown

Extract:

Instead of just fixing worn-out joints with metal and plastic, NITRO (Novel Innovations for Tissue Regeneration in Osteoarthritis) teams are working to regrow real, living tissue, returning joints to their healthy state and eliminating evidence of disease.

In two years, NITRO teams hit aggressive preclinical milestones, regenerating both cartilage and bone in osteoarthritic animal models. They are now working to complete the IND-enabling studies required to secure FDA concurrence to begin first-in-human clinical trials next year.

Led by ARPA-H Program Manager Ross Uhrich, DMD, MBA, NITRO teams are reshaping regenerative medicine across all stages of the OA continuum with new approaches in the program’s three technical areas: targeted bone regeneration, targeted cartilage regeneration, and total knee implants composed of living human tissue.

Martin Borch-Jensen writes a detailed analysis on the lack of the right datasets, which would hinder even highly advanced AI from producing breakthroughs in human longevity. AI's success in language and knowledge work cannot simply transfer to longevity research because biological data at the physiological and organismal layers where age-related diseases actually live is scarce, hard to generate, and slow to verify. Unlike protein folding or code, there are few corpora of highly-detailed longitudinal measurements; they also lack causal, task-relevant data for conditions like Alzheimer's or heart failure. What's more, clinical trial feedback loops take years. To unlock AI's potential in longevity, we need to deliberately generate the right kinds of data now: rich, multi-layer, longitudinal human studies which can be paired with faster experimental loops for causal hypothesis testing in the future. Because this data takes years to mature regardless of how quickly AI improves, the time to start is immediately.

Ukraine's astounding innovation and scaling in drone production has drastically changed the reality behind the war and assumptions from recent years. Previous calculations underlying calls to end support for Ukraine have been proven wrong, as Ukraine's production of millions of inexpensive drones could be bolstered by single-digit billions in aid.

The essay gets into specifics with numbers and convincingly makes the case for supporting Ukraine's drone industry. This is important to the sub, as defending Ukraine against the Russian invasion is a pivotal struggle against a global authoritarian power.

Standard preventive measures including the recombinant shingles vaccine, annual influenza vaccination, COVID-19 vaccination to prevent severe infection, and prompt antiviral treatment of clinically relevant herpesvirus reactivations should be part of medical guidance for brain health.