I had to max him out entirely. Also, I gotta say, running him with Chen, Endmin and Gilberta is probably the most fun I've had playing this game. The combos all proc and they all mesh so well.
I usually enjoy playing Plight mode because I like the challenge of these fights. I tend to E2 a lot of characters, but obviously it tends to trivialize combat (please let us turn off eidolons hoyo). Though, this current Plight was a huge challenge, E2 Acheron was obviously not enough DPS even with E2 MBlade, E2 Castorice Remembrance team was dead in a ditch with the quantum res, even Elation teams (both E2 Lv999 and E2 Eva) couldn't clear this fight for me. But, that's when I thought "well, how about main DPS E2 Evernight?"
I took several attempts and a lot of it was RNG with enemies hitting MBlade or not, but eventually I was able to clear it on the last possible turn. Honestly, wish I had recorded, I felt proud of myself LOL.
Anyway, for those wondering, yes, this Plight is clearable with E2S1 Evernight, E2S1MBlade, E2S2 Cyrene, and E2S1 Hyacine. It just takes being thoughtful of when you're using MBlade ults. And, this also made me enjoy playing Main DPS Evernight. She's literally the only one who could manage this for me.