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r/7_HOPE_Alliance

▲ 7 r/7_HOPE_Alliance

NY Bill S8925A

Calling All Advocates the fiscal year is almost over but we still need to stay VIGILANT!!!

🚨 NEW YORK 7-OH BILL ALERT — ACTION NEEDED 🚨

New York Senate Bill S8925A is now scheduled for consideration in the Senate Consumer Protection Committee on:

📅 May 20, 2026

🕥 10:30 AM

📍 Room 804 LOB

This bill would severely restrict or effectively eliminate most 7-hydroxymitragynine products currently on the market by imposing extremely low allowable limits.

This is NOT the time to stay silent.

If 7-OH has helped your quality of life, helped you stay away from illicit opioids, helped with pain, work, motivation, or daily functioning — NOW is the time to respectfully speak up.

📞 CONTACT THE SENATE CONSUMER PROTECTION COMMITTEE MEMBERS:

• Jeremy Cooney (Committee Chair)

Albany Office: (518) 455-2485

• Leroy Comrie

(518) 455-3531

• Pamela Helming

(518) 455-2366

• Rachel May

(518) 455-2111

• Roxanne Persaud

(518) 455-2788

• Patricia Fahy

(518) 455-2225

Emails for Senate Consumer Protection Committee

Jeremy Cooney (Chair)

cooney@nysenate.gov

Leroy Comrie

comrie@nysenate.gov

Pamela Helming

helming@nysenate.gov

Rachel May

may@nysenate.gov

Roxanne Persaud

Persaud@nysenate.gov

Patricia Fahy

Fahy@nysenate.gov

📢 MESSAGE TO LAWMAKERS:

Please regulate responsibly — don’t push consumers toward dangerous illicit opioids by banning products adults rely on.

Support:

✔ Age restrictions

✔ Testing requirements

✔ Labeling standards

✔ Responsible retail controls

But oppose prohibition that removes access entirely.

Keep calls respectful, calm, and professional. Angry calls hurt the cause.

Even a 2-minute phone call matters.

Example:

“Hi, my name is ___ and I’m asking the Senator to oppose S8925A as written. I support reasonable regulation and safety standards, but not prohibition of products many adults rely on. Please consider consumer harm reduction and personal freedom before supporting this bill.”

Share this everywhere. The hearing is May 20.

reddit.com
u/Aggravating-Sky7564 — 7 days ago
▲ 19 r/7_HOPE_Alliance

The “7oh Binds Stronger Than Morphine” Claim Is Based on a Misreading of the Data

There’s a lot of misinformation going around about 7oh because people are misreading receptor binding studies.

One of the biggest claims being repeated is that 7oh binds stronger to MOR than morphine. That is not what the data shows.

What the studies actually show is that 7oh binds much stronger than mitragynine, but much weaker than morphine.

From Obeng et al. 2021, which directly compared mitragynine, 7oh, and morphine side by side in human mu opioid receptors:

Mitragynine Ki = 709 nM

7oh Ki = 77.9 nM

Morphine Ki = 4.19 nM

Lower Ki = stronger binding affinity.

So yes, 7oh binds about 14 to 22 times stronger at MOR than mitragynine.

But 7oh also binds about 14 to 22 times WEAKER at MOR than morphine.

A lot of people are repeating the “14x stronger” claim without mentioning that the comparison was against mitragynine, not morphine.

This misunderstanding has been repeated so often that many people now believe 7oh has stronger MOR binding than morphine, when the actual receptor binding data shows the opposite.

Obeng 2021 is considered one of the strongest references on this topic because it tested all three compounds in the same study using human MORs instead of pulling numbers from unrelated studies.

EDIT: I added a link in the comments to the Obeng 2021 study that was referenced in this post.

u/Open-Bowl-9572 — 13 days ago